Transabdominal approach for renal cell carcinoma with supradiaphragmatic tumor thrombus: description of a modified technique and indications for treatment

Guoliang Wang, Hai Bi, Jianfei Ye, Hongxian Zhang, Xiaofei Hou, Cheng Liu, Min Qiu, Yu Tian, Dharam Kaushik, Lulin Ma

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: We investigated the safety and effectiveness of a modified transabdominal approach for renal cell carcinoma (RCC) with a supradiaphragmatic inferior vena cava (IVC) tumor thrombus (TT). Methods: Eight patients underwent radical nephrectomy with removal of a supradiaphragmatic IVC-TT through an abdominal incision using a transdiaphragmatic approach in Peking University Third Hospital from April 2015 to January 2018. We modified this technique using a Foley catheter balloon to avoid piggyback liver mobilization. Results: All patients underwent successful operations. The median operative time was 7 hours 23 minutes. The median estimated blood loss was 2963 mL. All patients received a blood transfusion with a median blood infusion volume of 2162 mL. Two patients with Budd–Chiari syndrome developed postoperative ascites and hydrothorax due to non-watertight repair of the diaphragm. During a follow-up of 11 to 44 months, only one patient died of liver metastasis and four patients developed distant metastasis without recurrence in the IVC. Conclusions: The modified transabdominal approach described herein has an encouraging safety profile and provides a surgical option for treatment of RCC with a supradiaphragmatic IVC-TT. More evidence concerning the beneficial role of this procedure will be elucidated in further studies.

Original languageEnglish (US)
JournalJournal of International Medical Research
Volume48
Issue number11
DOIs
StatePublished - 2020

Keywords

  • Renal cell carcinoma
  • inferior vena cava
  • modified technique
  • nephrectomy
  • supradiaphragmatic tumor thrombus
  • transabdominal approach

ASJC Scopus subject areas

  • Biochemistry
  • Biochemistry, medical
  • Cell Biology

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