Traffic Jams during Vesicle Cycling Lead to Synaptic Depression

Jun Hee Kim, Henrique von Gersdorff

Research output: Contribution to journalShort survey

5 Scopus citations

Abstract

During prolonged stimulation, fusion of thousands of synaptic vesicles poses a challenge for the temporal and spatial coordination of exocytosis and endocytosis. In this issue of Neuron, Hosoi and colleagues reveal that [Ca2+]i-microdomains trigger compensatory endocytosis. Block of endocytosis enhances short-term depression by delaying vesicle recruitment to docking sites on active zones.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalNeuron
Volume63
Issue number2
DOIs
StatePublished - Jul 30 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Traffic Jams during Vesicle Cycling Lead to Synaptic Depression'. Together they form a unique fingerprint.

  • Cite this