Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma

Julianna Aleathea Burzynski, Juan J. Toro, Rakhi Chhaganbhai Patel, Shuko Lee, Rebecca Elizabeth Greene, Jose Leonel Ochoa-Bayona, Christopher Raymond Frei, Cesar O. Freytes

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36 Scopus citations

Abstract

Toxicity associated with a second autologous peripheral blood stem cell transplant (APBSCT) in patients who relapse following initial APBSCT for multiple myeloma (MM) has not been well described. We conducted a retrospective, case-series of 25 consecutive patients who received a second APBSCT for relapsed or progressive disease following prior APBSCT to describe associated toxicity. Grade 3 or 4 toxicities were observed in 92% of patients after each APBSCT. More patients developed an elevated serum creatinine (4%vs. 36%; p = 0.011) following the second APBSCT. Median time to neutrophil engraftment was 10 days following both transplants (p = 0.428). Platelet engraftment was delayed by 2 days after the second APBSCT (median 12 vs.14 days; p < 0.025). There were two deaths before day 100. In conclusion, patients who undergo a second APBSCT for relapsed MM experience more nephrotoxicity. Delayed platelet engraftment and an 8% treatment-related mortality were observed following the second APBSCT.

Original languageEnglish (US)
Pages (from-to)1442-1447
Number of pages6
JournalLeukemia and Lymphoma
Volume50
Issue number9
DOIs
StatePublished - Dec 1 2009

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Keywords

  • Multiple myeloma
  • autologous
  • hematopoietic stem cell transplantation salvage therapy
  • toxicity

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Burzynski, J. A., Toro, J. J., Patel, R. C., Lee, S., Greene, R. E., Ochoa-Bayona, J. L., Frei, C. R., & Freytes, C. O. (2009). Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma. Leukemia and Lymphoma, 50(9), 1442-1447. https://doi.org/10.1080/10428190903085936