Towards an aging-specific cognitive phenotype: The freedom house study

Donald R Royall, Ray Palmer, Laura K. Chiodo, Marsha J. Polk

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Study Context: The authors have previously reported latent growth curve (LGC) models of 3-year change in multiple cognitive measures among successfully aging volunteers. In this analysis, the authors apply growth mixture modeling (GMM) to demonstrate homogeneous subsets among them with discriminable trajectories. Only one trajectory class can be interpreted as the effect of Aging Proper. The goal of the study was to describe an aging-specific cognitive phenotype (ASCP). Methods: Five hundred forty-seven noninstitutionalized septuagenarian and octogenarian volunteers, residing in a comprehensive care retirement community, were assessed longitudinally on a comprehensive battery of brief psychometric measures.Results: All variables held more than one latent class. Members of an a priori defined "Aging Proper" class were highly concordant across measures, and allowed the aging-specific cognitive phenotype (ASCP) to be examined. The ASCP was characterized by simultaneous decline in visuospatial function, coupled with improving verbal fluency. The ASCP was not associated with decline in memory task performance.Conclusions: Previously reported age-related declines in memory are more likely to represent the effects of comorbid disease and not aging per se. The ASCP is more consistent with earlier "Right Hemisphere" models of aging and could provide clues to the mechanisms underlying true aging-related cognitive changes.

Original languageEnglish (US)
Pages (from-to)245-265
Number of pages21
JournalExperimental Aging Research
Volume40
Issue number3
DOIs
StatePublished - May 27 2014

Fingerprint

Phenotype
Volunteers
Retirement
Task Performance and Analysis
Growth
Psychometrics
Cognitive Aging

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging
  • Psychology(all)
  • Arts and Humanities (miscellaneous)
  • Medicine(all)

Cite this

Towards an aging-specific cognitive phenotype : The freedom house study. / Royall, Donald R; Palmer, Ray; Chiodo, Laura K.; Polk, Marsha J.

In: Experimental Aging Research, Vol. 40, No. 3, 27.05.2014, p. 245-265.

Research output: Contribution to journalArticle

@article{ad53a9da9968453ba742b2374031154e,
title = "Towards an aging-specific cognitive phenotype: The freedom house study",
abstract = "Background/Study Context: The authors have previously reported latent growth curve (LGC) models of 3-year change in multiple cognitive measures among successfully aging volunteers. In this analysis, the authors apply growth mixture modeling (GMM) to demonstrate homogeneous subsets among them with discriminable trajectories. Only one trajectory class can be interpreted as the effect of Aging Proper. The goal of the study was to describe an aging-specific cognitive phenotype (ASCP). Methods: Five hundred forty-seven noninstitutionalized septuagenarian and octogenarian volunteers, residing in a comprehensive care retirement community, were assessed longitudinally on a comprehensive battery of brief psychometric measures.Results: All variables held more than one latent class. Members of an a priori defined {"}Aging Proper{"} class were highly concordant across measures, and allowed the aging-specific cognitive phenotype (ASCP) to be examined. The ASCP was characterized by simultaneous decline in visuospatial function, coupled with improving verbal fluency. The ASCP was not associated with decline in memory task performance.Conclusions: Previously reported age-related declines in memory are more likely to represent the effects of comorbid disease and not aging per se. The ASCP is more consistent with earlier {"}Right Hemisphere{"} models of aging and could provide clues to the mechanisms underlying true aging-related cognitive changes.",
author = "Royall, {Donald R} and Ray Palmer and Chiodo, {Laura K.} and Polk, {Marsha J.}",
year = "2014",
month = "5",
day = "27",
doi = "10.1080/0361073X.2014.896665",
language = "English (US)",
volume = "40",
pages = "245--265",
journal = "Experimental Aging Research",
issn = "0361-073X",
publisher = "Taylor and Francis Ltd.",
number = "3",

}

TY - JOUR

T1 - Towards an aging-specific cognitive phenotype

T2 - The freedom house study

AU - Royall, Donald R

AU - Palmer, Ray

AU - Chiodo, Laura K.

AU - Polk, Marsha J.

PY - 2014/5/27

Y1 - 2014/5/27

N2 - Background/Study Context: The authors have previously reported latent growth curve (LGC) models of 3-year change in multiple cognitive measures among successfully aging volunteers. In this analysis, the authors apply growth mixture modeling (GMM) to demonstrate homogeneous subsets among them with discriminable trajectories. Only one trajectory class can be interpreted as the effect of Aging Proper. The goal of the study was to describe an aging-specific cognitive phenotype (ASCP). Methods: Five hundred forty-seven noninstitutionalized septuagenarian and octogenarian volunteers, residing in a comprehensive care retirement community, were assessed longitudinally on a comprehensive battery of brief psychometric measures.Results: All variables held more than one latent class. Members of an a priori defined "Aging Proper" class were highly concordant across measures, and allowed the aging-specific cognitive phenotype (ASCP) to be examined. The ASCP was characterized by simultaneous decline in visuospatial function, coupled with improving verbal fluency. The ASCP was not associated with decline in memory task performance.Conclusions: Previously reported age-related declines in memory are more likely to represent the effects of comorbid disease and not aging per se. The ASCP is more consistent with earlier "Right Hemisphere" models of aging and could provide clues to the mechanisms underlying true aging-related cognitive changes.

AB - Background/Study Context: The authors have previously reported latent growth curve (LGC) models of 3-year change in multiple cognitive measures among successfully aging volunteers. In this analysis, the authors apply growth mixture modeling (GMM) to demonstrate homogeneous subsets among them with discriminable trajectories. Only one trajectory class can be interpreted as the effect of Aging Proper. The goal of the study was to describe an aging-specific cognitive phenotype (ASCP). Methods: Five hundred forty-seven noninstitutionalized septuagenarian and octogenarian volunteers, residing in a comprehensive care retirement community, were assessed longitudinally on a comprehensive battery of brief psychometric measures.Results: All variables held more than one latent class. Members of an a priori defined "Aging Proper" class were highly concordant across measures, and allowed the aging-specific cognitive phenotype (ASCP) to be examined. The ASCP was characterized by simultaneous decline in visuospatial function, coupled with improving verbal fluency. The ASCP was not associated with decline in memory task performance.Conclusions: Previously reported age-related declines in memory are more likely to represent the effects of comorbid disease and not aging per se. The ASCP is more consistent with earlier "Right Hemisphere" models of aging and could provide clues to the mechanisms underlying true aging-related cognitive changes.

UR - http://www.scopus.com/inward/record.url?scp=84899812753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899812753&partnerID=8YFLogxK

U2 - 10.1080/0361073X.2014.896665

DO - 10.1080/0361073X.2014.896665

M3 - Article

C2 - 24785590

AN - SCOPUS:84899812753

VL - 40

SP - 245

EP - 265

JO - Experimental Aging Research

JF - Experimental Aging Research

SN - 0361-073X

IS - 3

ER -