Towards a healthy human model of neural disorders of movement

Howard Poizner; Jack Lancaster; Eugene Tunik; Shalini Narayana; Crystal Franklin; William Rogers; Xiaoyan Li; Peter T. Fox; Donald A. Robin

doi:10.1109/TNSRE.2012.2184769

Towards a healthy human model of neural disorders of movement

Howard Poizner
, Jack Lancaster
, Eugene Tunik
, Shalini Narayana
, Crystal Franklin
, William Rogers
, Xiaoyan Li
, Peter T. Fox
, Donald A. Robin

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.

Original language	English (US)
Article number	6138324
Pages (from-to)	853-857
Number of pages	5
Journal	IEEE Transactions on Neural Systems and Rehabilitation Engineering
Volume	20
Issue number	6
DOIs	https://doi.org/10.1109/TNSRE.2012.2184769
State	Published - 2012

Keywords

Apraxia
brain imaging
kinematics
motor control

ASJC Scopus subject areas

Internal Medicine
General Neuroscience
Biomedical Engineering
Rehabilitation

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10.1109/TNSRE.2012.2184769

Cite this

@article{6c2260e8dfef4aebbc13b71613e2d480,

title = "Towards a healthy human model of neural disorders of movement",

abstract = "A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.",

keywords = "Apraxia, brain imaging, kinematics, motor control",

author = "Howard Poizner and Jack Lancaster and Eugene Tunik and Shalini Narayana and Crystal Franklin and William Rogers and Xiaoyan Li and Fox, \{Peter T.\} and Robin, \{Donald A.\}",

note = "Funding Information: Manuscript received September 16, 2011; revised January 01, 2012; accepted January 12, 2012. Date of publication January 23, 2012; date of current version November 02, 2012. The work of S. Narayana was supported by R21 DC009467. The work of S. L and D. Robin was supported by R01 DC006243. The work of H. Poizner was supported in part by ONR MURI under Award N00014-10-1-0072 and in part by the National Institutes of Health (NIH) under Grant 2 R01 NS036449. The work of E. Tunik was supported by the NIH under grant K01 HD059983. This work was also supported by the National Science Foundation (NSF) under Grant ENG-1137279 (EFRI M3C) and Grant SBE-0542013 to the Temporal Dynamics of Learning Center, an NSF Science of Learning Center.",

year = "2012",

doi = "10.1109/TNSRE.2012.2184769",

language = "English (US)",

volume = "20",

pages = "853--857",

journal = "IEEE Transactions on Neural Systems and Rehabilitation Engineering",

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publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "6",

}

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T1 - Towards a healthy human model of neural disorders of movement

AU - Poizner, Howard

AU - Lancaster, Jack

AU - Tunik, Eugene

AU - Narayana, Shalini

AU - Franklin, Crystal

AU - Rogers, William

AU - Li, Xiaoyan

AU - Fox, Peter T.

AU - Robin, Donald A.

N1 - Funding Information: Manuscript received September 16, 2011; revised January 01, 2012; accepted January 12, 2012. Date of publication January 23, 2012; date of current version November 02, 2012. The work of S. Narayana was supported by R21 DC009467. The work of S. L and D. Robin was supported by R01 DC006243. The work of H. Poizner was supported in part by ONR MURI under Award N00014-10-1-0072 and in part by the National Institutes of Health (NIH) under Grant 2 R01 NS036449. The work of E. Tunik was supported by the NIH under grant K01 HD059983. This work was also supported by the National Science Foundation (NSF) under Grant ENG-1137279 (EFRI M3C) and Grant SBE-0542013 to the Temporal Dynamics of Learning Center, an NSF Science of Learning Center.

PY - 2012

Y1 - 2012

N2 - A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.

AB - A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.

KW - Apraxia

KW - brain imaging

KW - kinematics

KW - motor control

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DO - 10.1109/TNSRE.2012.2184769

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AN - SCOPUS:84869434984

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ER -

Towards a healthy human model of neural disorders of movement

Abstract

Keywords

ASJC Scopus subject areas

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