Toward understanding the role of methylation in aldosterone-sensitive Na+ transport

James D. Stockand, Robert S. Edinger, Douglas C. Eaton, John P. Johnson

Research output: Contribution to journalArticle

15 Scopus citations


Proper endocrine regulation of Na+ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na+ reabsorption by activating luminal Na+ channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na+ channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na+ reabsorption.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalNews in Physiological Sciences
Issue number4
StatePublished - Aug 1 2000


ASJC Scopus subject areas

  • Physiology

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