Proper endocrine regulation of Na+ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na+ reabsorption by activating luminal Na+ channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na+ channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na+ reabsorption.
|Original language||English (US)|
|Number of pages||5|
|Journal||News in Physiological Sciences|
|State||Published - Aug 1 2000|
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