Abstract
Proper endocrine regulation of Na+ reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na+ reabsorption by activating luminal Na+ channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na+ channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na+ reabsorption.
Original language | English (US) |
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Pages (from-to) | 161-165 |
Number of pages | 5 |
Journal | News in Physiological Sciences |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - Aug 2000 |
ASJC Scopus subject areas
- Physiology