TY - JOUR
T1 - Toward a rational pharmacotherapy of depression
AU - Stern, S. L.
AU - Rush, A. J.
AU - Mendels, J.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The authors review several approaches that show promise for predicting which antidepressant medication will be best for a particular patient and for achieving maximum benefit from each drug. These include delineation of clinical and historical characteristics associated with response to various drugs, use of psychological tests, assessment of biochemical and electroencephalographic parameters, evaluation of mood response to amphetamine, determination of acetylator status, and measurement of plasma tricyclic levels and degree of inhibition of platelet monoamine oxidase. The authors believe that the use of these approaches may improve the authors ability to help depressed patients.
AB - The authors review several approaches that show promise for predicting which antidepressant medication will be best for a particular patient and for achieving maximum benefit from each drug. These include delineation of clinical and historical characteristics associated with response to various drugs, use of psychological tests, assessment of biochemical and electroencephalographic parameters, evaluation of mood response to amphetamine, determination of acetylator status, and measurement of plasma tricyclic levels and degree of inhibition of platelet monoamine oxidase. The authors believe that the use of these approaches may improve the authors ability to help depressed patients.
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U2 - 10.1176/ajp.137.5.545
DO - 10.1176/ajp.137.5.545
M3 - Article
C2 - 7369397
AN - SCOPUS:0018867308
VL - 137
SP - 545
EP - 552
JO - American Journal of Psychiatry
JF - American Journal of Psychiatry
SN - 0002-953X
IS - 5
ER -