Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Paul A. Wender; Michael K. Hilinski; Nicolas Soldermann; Susan L. Mooberry

doi:10.1021/ol060233g

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Paul A. Wender, Michael K. Hilinski, Nicolas Soldermann, Susan L. Mooberry

Pharmacology

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

Original language	English (US)
Pages (from-to)	1507-1510
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/ol060233g
State	Published - Mar 30 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol060233g

Cite this

@article{3a7a0fdc36c24b169b130d78cb8577e0,

title = "Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue",

abstract = "A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.",

author = "Wender, {Paul A.} and Hilinski, {Michael K.} and Nicolas Soldermann and Mooberry, {Susan L.}",

year = "2006",

month = mar,

day = "30",

doi = "10.1021/ol060233g",

language = "English (US)",

volume = "8",

pages = "1507--1510",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

AU - Wender, Paul A.

AU - Hilinski, Michael K.

AU - Soldermann, Nicolas

AU - Mooberry, Susan L.

PY - 2006/3/30

Y1 - 2006/3/30

N2 - A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

AB - A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

UR - http://www.scopus.com/inward/record.url?scp=33645949745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645949745&partnerID=8YFLogxK

U2 - 10.1021/ol060233g

DO - 10.1021/ol060233g

M3 - Article

C2 - 16562928

AN - SCOPUS:33645949745

VL - 8

SP - 1507

EP - 1510

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 7

ER -

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this