Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Paul A. Wender; Michael K. Hilinski; Nicolas Soldermann; Susan L. Mooberry

doi:10.1021/ol060233g

Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Paul A. Wender, Michael K. Hilinski, Nicolas Soldermann, Susan L. Mooberry

Department of Pharmacology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

Original language	English (US)
Pages (from-to)	1507-1510
Number of pages	4
Journal	Organic Letters
Volume	8
Issue number	7
DOIs	https://doi.org/10.1021/ol060233g
State	Published - Mar 30 2006

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol060233g

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abstract = "A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.",

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AU - Hilinski, Michael K.

AU - Soldermann, Nicolas

AU - Mooberry, Susan L.

PY - 2006/3/30

Y1 - 2006/3/30

N2 - A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

AB - A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

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Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Abstract

ASJC Scopus subject areas

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