Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue

Paul A. Wender, Michael K. Hilinski, Nicolas Soldermann, Susan L. Mooberry

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.

Original languageEnglish (US)
Pages (from-to)1507-1510
Number of pages4
JournalOrganic Letters
Volume8
Issue number7
DOIs
StatePublished - Mar 30 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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