Abstract
A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1507-1510 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 8 |
| Issue number | 7 |
| DOIs | |
| State | Published - Mar 30 2006 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Wender, P. A., Hilinski, M. K., Soldermann, N., & Mooberry, S. L. (2006). Total synthesis and biological evaluation of 11-desmethyllaulimalide, a highly potent simplified laulimalide analogue. Organic Letters, 8(7), 1507-1510. https://doi.org/10.1021/ol060233g