Abstract
A step-economical synthesis of 11-desmethyllaulimalide (2) is reported. This simplified analogue is available through an improved second-generation synthetic approach to the laulimalides, in a shorter step count and from much less expensive starting material than the parent compound. This new lead retains the anticancer function of laulimalide.
Original language | English (US) |
---|---|
Pages (from-to) | 1507-1510 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 7 |
DOIs | |
State | Published - Mar 30 2006 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry