TY - JOUR
T1 - Topographical specialization of prostaglandin function in late pregnancy and at parturition in the baboon
AU - Nathanielsz, Peter W.
AU - Smith, Gordon
AU - Wu, Wen
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2004/2
Y1 - 2004/2
N2 - Prostaglandins play key central roles in both the maintenance of pregnancy and parturition. Extensive data exist from studies in human pregnancy but the needs of clinical management and the inability to conduct carefully controlled perturbation studies in human pregnancy make it necessary to obtain information from nonhuman primate models. We have used the pregnant baboon to evaluate production, metabolism and receptor mediated actions of prostaglandins in late gestation to demonstrate that expression of key genes is tightly controlled in enzyme-specific, gestation age-specific, tissue-specific and uterine region-specific fashion.
AB - Prostaglandins play key central roles in both the maintenance of pregnancy and parturition. Extensive data exist from studies in human pregnancy but the needs of clinical management and the inability to conduct carefully controlled perturbation studies in human pregnancy make it necessary to obtain information from nonhuman primate models. We have used the pregnant baboon to evaluate production, metabolism and receptor mediated actions of prostaglandins in late gestation to demonstrate that expression of key genes is tightly controlled in enzyme-specific, gestation age-specific, tissue-specific and uterine region-specific fashion.
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U2 - 10.1016/j.plefa.2003.04.008
DO - 10.1016/j.plefa.2003.04.008
M3 - Article
C2 - 14683693
AN - SCOPUS:0942290508
VL - 70
SP - 199
EP - 206
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
SN - 0952-3278
IS - 2
ER -