Topical Prostaglandin E2 in the Treatment of Acute Upper Gastrointestinal Tract Hemorrhage: A Prospective, Randomized, Double-blind Study

Barry A. Levine, Kenneth R. Sirinek, Harold V. Gaskill

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We performed a prospective, randomized, double-blind study to assess the efficacy of topical prostaglandin E2 (PGE2) in altering the course of patients with severe upper gastrointestinal tract hemorrhage. Forty-four patients with life-threatening, endoscopically proven hemorrhage were randomly allocated to receive either PGE2 or placebo for seven days. Severity of mucosal injury, determined by endoscopy, was scored both before and after completion of treatment. There were no significant differences between groups in either transfusion requirements or successful outcomes. However, the PGE2 group had significantly improved endoscopic injury scores while the placebo group did not. Therefore, topical PGE2 does not control acute hemorrhage from established upper gastrointestinal tract lesions, but it does result in an accelerated healing of established lesions.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalArchives of Surgery
Volume120
Issue number5
DOIs
StatePublished - May 1985

ASJC Scopus subject areas

  • Surgery

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