Topical fluoride for caries prevention

Robert I. Weyant, Sharon L. Tracy, Theresa Anselmo, Eugenio D. Beltrán-Aguilar, Kevin J. Donly, William A. Frese, Philippe P. Hujoel, Timothy Iafolla, William Kohn, Jayanth Kumar, Steven M. Levy, Norman Tinanoff, J. Timothy Wright, Domenick Zero, Krishna Aravamudhan, Julie Frantsve-Hawley, Daniel M. Meyer

Research output: Contribution to journalArticlepeer-review

234 Scopus citations


Background: A panel of experts convened by the American Dental Association (ADA) Council on Scientific Affairs presents evidence-based clinical recommendations regarding professionally applied and prescription-strength, home-use topical fluoride agents for caries prevention. These recommendations are an update of the 2006 ADA recommendations regarding professionally applied topical fluoride and were developed by using a new process that includes conducting a systematic review of primary studies. types of Studies Reviewed. The authors conducted a search of MEDLINE and the Cochrane Library for clinical trials of professionally applied and prescription-strength topical fluoride agents-including mouthrinses, varnishes, gels, foams and pastes-with caries increment outcomes published in English through October 2012. Results: The panel included 71 trials from 82 articles in its review and assessed the efficacy of various topical fluoride cariespreventive agents. The panel makes recommendations for further research. Practical Implications. The panel recommends the following for people at risk of developing dental caries:2.26 percent fluoride varnish or 1.23 percent fluoride (acidulated phosphate fluoride) gel, or a prescription-strength, home-use 0.05 percent fluoride gel or paste or 0.09 percent fluoride mouthrinse for patients 6 years or older. Only 2.26 percent fluoride varnish is recommended for children younger than 6 years. The strengths of the recommendations for the recommended products varied from "in favor" to "expert opinion for." As part of the evidence-based approach to care, these clinical recommendations should be integrated with the practitioner's professional judgment and the patient's needs and preferences.

Original languageEnglish (US)
Pages (from-to)1279-1291
Number of pages13
JournalJournal of the American Dental Association
Issue number11
StatePublished - Nov 2013
Externally publishedYes


  • Caries
  • Caries prevention
  • Evidence-based dentistry
  • Fluoride
  • Practice guidelines
  • Preventive dentistry

ASJC Scopus subject areas

  • Dentistry(all)


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