Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells

Jeong Hyeon Sohn, Puran S. Bora, Hye Jung Suk, Hector Molina, Henry J. Kaplan, Nalini S. Bora

Research output: Contribution to journalArticle

147 Scopus citations

Abstract

Systemic tolerance can be induced by the introduction of antigen into an immune-privileged site. Here we investigated the role of complement in the induction of tolerance after intraocular injection. We found that the development of antigen-specific tolerance is dependent on a complement activation product. The ligation of the complement C3 activation product iC3b to complement receptor type 3 (the iC3b receptor) on antigen-presenting cells resulted in the sequential production of transforming growth factor-β2 and interleukin-10, which is essential for the induction of tolerance. These observations may extend to the development of both neonatal tolerance and other forms of acquired tolerance.

Original languageEnglish (US)
Pages (from-to)206-212
Number of pages7
JournalNature Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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