TNF and lymphotoxin β cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes

Dmitry V. Kuprash, Marat B. Alimzhanov, Alexei V Tumanov, Arthur O. Anderson, Klaus Pfeffer, Sergei A. Nedospasov

Research output: Contribution to journalArticle

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Abstract

Inactivation of genes encoding members of TNF and TNF receptor families reveal their divergent roles in the formation and function of secondary lymphoid organs. Most lymphotoxin α (ltα)- and all lymphotoxin β receptor (ltβr)-deficient mice are completely devoid of lymph nodes (LNs); however, most lymphotoxin β (ltβ)-deficient mice develop mesenteric LNs. Tnf- and tnfrp55-deficient mice develop a complete set of LNs, while ltβ/tnfrp55 double-deficient mice lack all LNs, demonstrating cooperation between LTβ and TNFRp55 in LN development. Now we report that ltβ/tnf double-deficient mice develop the same set of mucosal LNs as do ltβ-deficient mice, suggesting that ligands other than TNF signal through TNFRp55 during LN development. These LNs retain distinct T and B cells areas; however, they lack follicular dendritic cell networks. Structures resembling germinal centers can be found in the LNs from immunized ltβ-deficient mice but not in ltβ/tnf double-deficient mice. Additionally, stromal components of the spleen and LNs appear to be more severely disturbed in ltβ/tnf double- deficient mice as compared with ltβ-deficient mice. We conclude that LTβ and TNF cooperate in the establishment of the correct microarchitecture of lymphoid organs.

Original languageEnglish (US)
Pages (from-to)6575-6580
Number of pages6
JournalJournal of Immunology
Volume163
Issue number12
StatePublished - Dec 28 1999
Externally publishedYes

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Lymphotoxin-alpha
Lymphoid Tissue
Lymph Nodes
Maintenance
Follicular Dendritic Cells
Germinal Center
Tumor Necrosis Factor Receptors
Gene Silencing
B-Lymphocytes
Spleen
Ligands
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

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TNF and lymphotoxin β cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. / Kuprash, Dmitry V.; Alimzhanov, Marat B.; Tumanov, Alexei V; Anderson, Arthur O.; Pfeffer, Klaus; Nedospasov, Sergei A.

In: Journal of Immunology, Vol. 163, No. 12, 28.12.1999, p. 6575-6580.

Research output: Contribution to journalArticle

Kuprash, Dmitry V. ; Alimzhanov, Marat B. ; Tumanov, Alexei V ; Anderson, Arthur O. ; Pfeffer, Klaus ; Nedospasov, Sergei A. / TNF and lymphotoxin β cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes. In: Journal of Immunology. 1999 ; Vol. 163, No. 12. pp. 6575-6580.
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AU - Kuprash, Dmitry V.

AU - Alimzhanov, Marat B.

AU - Tumanov, Alexei V

AU - Anderson, Arthur O.

AU - Pfeffer, Klaus

AU - Nedospasov, Sergei A.

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