TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus

Ahmed S. Elshikha, Xiang Yu Teng, Nathalie Kanda, Wei Li, Seung Chul Choi, Georges Abboud, Morgan Terrell, Kristianna Fredenburg, Laurence Morel

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We report a novel model of lupus-associated cardiovascular pathology accelerated by the TLR7 agonist R848 in lupus-prone B6.Sle1.Sle2.Sle3 (TC) mice. R848-treated TC mice but not non-autoimmune C57BL/6 (B6) controls developed microvascular inflammation and myocytolysis with intracellular vacuolization. This histopathology was similar to antibody-mediated rejection after heart transplant, although it did not involve complement. The TC or B6 recipients of serum or splenocytes from R848-treated TC mice developed a reactive cardiomyocyte hypertrophy, which also presents spontaneously in old TC mice as well as in TC.Rag-/- mice that lack B and T cells. Each of these cardiovascular lesions correspond to abnormalities that have been reported in lupus patients. Lymphoid and non-lymphoid immune cells as well as soluble factors contribute to lupus-associated cardiovascular lesions in TC mice, which can now be dissected using this model with and without R848 treatment.

Original languageEnglish (US)
Article number914468
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Jul 4 2022
Externally publishedYes

Keywords

  • autoimmunity
  • cardiovascular disease
  • lupus
  • mouse models
  • TLR7

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'TLR7 Activation Accelerates Cardiovascular Pathology in a Mouse Model of Lupus'. Together they form a unique fingerprint.

Cite this