Titanium surface roughness alters responsiveness of MG63 osteoblast- like cells to 1α,25-(OH)2D3

B. D. Boyan, R. Batzer, K. Kieswetter, Y. Liu, D. L. Cochran, S. Szmuckler-Moncler, D. D. Dean, Z. Schwartz

Research output: Contribution to journalArticlepeer-review

345 Scopus citations


The effect of titanium surface roughness on the cellular response of circulating 1α,25-(OH)2D3 hormones was studied. The cells showed a significant increase in alkaline phosphatase activity as the surface became rougher. Addition of 1α,25-(OH)2D3 to the cultures caused a dose-dependent stimulation of alkaline phosphatase activity that was synergistic with the effect caused by surface roughness alone. The inhibitory effect of surface roughness on cell number was unaffected by 1α,25-(OH)2D3 except on the sandblasted surface. Bone cell response to systemic hormones was modified by surface roughness and surface roughness increased the responsiveness of MG63 cells to 1α,25-(OH)2D3.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalJournal of Biomedical Materials Research
Issue number1
StatePublished - Jan 1 1998


  • 1α,25- (OH)D
  • Differentiation
  • Implant
  • Local factor
  • Osteoblasts
  • Surface roughness
  • Titanium

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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