Tissue-specific implications of mitochondrial alterations in aging

Danhui Liu, Hongzhi Li, Jianxin Lu, Yidong Bai

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Aging is a multifactorial process during which physiological alterations occur in all tissues. A decline in mitochondrial function plays an important role in the process of aging and in aging-associated diseases. The mitochondrial genome encodes 13 essential subunits of protein complexes belonging to the oxidative phosphorylation system, while most of the mitochondriarelated genes are encoded by the nuclear genome. Coordination between the nucleus and mitochondria is crucial for the regulation of mitochondrial biogenesis and function. In this review, we will discuss aging-related mitochondrial dysfunction in various tissues and its implication in aging-related diseases and the aging process.

Original languageEnglish (US)
Pages (from-to)734-747
Number of pages14
JournalFrontiers in Bioscience - Elite
Volume5 E
Issue number2
DOIs
StatePublished - Jan 1 2013

Keywords

  • Aging
  • Agingassociated diseases
  • Mitochondria
  • Mitochondrial regulation
  • MtDNA mutation
  • Review
  • Tissue-specific

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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