Tissue-specific expression of a Drosophila calcium-activated potassium channel

Marie N. Becker, Robert Brenner, Nigel S. Atkinson

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development. It is expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. The promoter has been cloned and shown to direct expression in the same pattern as the endogenous gene in both neural and epithelial-derived cells. During pupariation and embryogenesis, slo is expressed in muscles many hours prior to the appearance of functional channels.

Original languageEnglish (US)
Pages (from-to)6250-6259
Number of pages10
JournalJournal of Neuroscience
Volume15
Issue number9
DOIs
StatePublished - Sep 1995
Externally publishedYes

Keywords

  • Ca-activated K channel
  • Drosophila
  • antibody
  • development
  • gene expression
  • reporter gene
  • slow-poke

ASJC Scopus subject areas

  • Neuroscience(all)

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