Abstract
The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development. It is expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. The promoter has been cloned and shown to direct expression in the same pattern as the endogenous gene in both neural and epithelial-derived cells. During pupariation and embryogenesis, slo is expressed in muscles many hours prior to the appearance of functional channels.
Original language | English (US) |
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Pages (from-to) | 6250-6259 |
Number of pages | 10 |
Journal | Journal of Neuroscience |
Volume | 15 |
Issue number | 9 |
DOIs | |
State | Published - Sep 1995 |
Keywords
- Ca-activated K channel
- Drosophila
- antibody
- development
- gene expression
- reporter gene
- slow-poke
ASJC Scopus subject areas
- Neuroscience(all)