Tissue-specific control of tissue-resident memory T cells

Yong Liu, Chaoyu Ma, Nu Zhang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Tissue-resident memory T (T RM ) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of T RM s. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of T RM s. Here, we discuss recent advances in the T RM field with a special emphasis on the interaction between local signals and T RM s in the context of individual tissue environment.

Original languageEnglish (US)
Pages (from-to)79-103
Number of pages25
JournalCritical Reviews in Immunology
Issue number2
StatePublished - 2018


  • CD4
  • CD8
  • IL-15
  • Infection
  • Memory
  • TGF-β

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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