Tissue-specific control of tissue-resident memory T cells

Tissue-resident memory T (T_RM) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of T_RMs. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of T_RMs. Here, we discuss recent advances in the T_RM field with a special emphasis on the interaction between local signals and T_RMs in the context of individual tissue environment.