Abstract
Tissue-resident memory T (T RM ) cells have emerged as a major component of T cell biology. Recent investigations have greatly advanced our understanding of T RM s. Common features have been discovered to distinguish memory T cells residing in various mucosal and non-mucosal tissues from their circulating counterparts. Given that most organs and tissues contain a unique microenvironment, local signal-induced tissue-specific features are tightly associated with the differentiation, homeostasis, and protective functions of T RM s. Here, we discuss recent advances in the T RM field with a special emphasis on the interaction between local signals and T RM s in the context of individual tissue environment.
Original language | English (US) |
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Pages (from-to) | 79-103 |
Number of pages | 25 |
Journal | Critical Reviews in Immunology |
Volume | 38 |
Issue number | 2 |
DOIs | |
State | Published - 2018 |
Keywords
- CD4
- CD8
- IL-15
- Infection
- Memory
- TGF-β
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology