Tissue plasminogen activating factor assisted removal of subretinal hemorrhage

G. A. Peyman, N. C. Nelson, W. Alturki, K. J. Blinder, C. L. Paris, U. R. Desai, C. A. Harper

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


We used tissue plasminogen activator activator (tPA) to aid in the surgical evacuation of subretinal hemorrhages. Subretinal hemorrhage secondary to a ruptured retinal macroaneurysm was treated in two patients. The surgical technique involved using a micropipette to fashion a small retinotomy through which tPA was injected into the subretinal space and through which the dissolved clot was removed. Visual acuity improved from counts fingers to 20/50 in one patient and from counts fingers to 20/70 in the other. Three additional patients, with massive subretinal hemorrhages secondary to age-related macular degeneration, were similarly treated. In one, visual acuity improved from counts fingers to 20/400; in two others, visual acuity was stabilized; in the first patient, at 20/300, and in the second patient at 20/400. The use of tPA minimizes surgical manipulation of the sensory retina and greatly reduces the size of the retinotomy required for evacuation of subretinal blood.

Original languageEnglish (US)
Pages (from-to)575-582
Number of pages8
JournalOphthalmic Surgery
Issue number10
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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