Time course of the disappearance of pineal noradrenaline following superior cervical ganglionectomy

W. W. Morgan, J. T. Hansen

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Pineal glands were collected from superior cervical ganglion-ectomized (SCGX) and sham-treated rats at time intervals following surgical manipulation. Pineal noradrenaline (NA) levels were quantitated by a radioisotopic-enzyme technique, or the pineals were examined by histofluorescence or electron microscopic techniques. A significant decline in pineal NA content was observed by 12 hours with a virtual disappearance of NA by 24 hours following SCGX. The depletion of NA content correlated with the disappearance of synaptic vesicles and the appearance of generalized fine structural degeneration of the sympathetic nerve endings in the pineals. Then results indicate that less than one day is required to remove all of the potentially, functional neurotransmitter from the denervated pineal gland. These observations agree closely with the time course of degeneration of other sympathetic nerve terminals following SCGX.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalExperimental Brain Research
Volume32
Issue number3
DOIs
StatePublished - Jul 1978

Keywords

  • Ganglionectomy
  • Neuronal degeneration
  • Noradrenaline
  • Pineal
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Neuroscience(all)

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