Tie Me Up, Tie Me Down: Inhibiting RNA Polymerase

Research output: Contribution to journalArticle

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Abstract

Mechanistic understanding of antibiotic action can yield crucial insights that aid in the design of new antibiotics. In this issue, Mukhopadhyay et al. (2008) uncover the mechanism by which the antibiotic myxopyronin inhibits bacterial RNA polymerase, suggesting a new target region in RNA polymerase for inhibitor design.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalCell
Volume135
Issue number2
DOIs
StatePublished - Oct 17 2008

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DNA-Directed RNA Polymerases
Anti-Bacterial Agents
Bacterial RNA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tie Me Up, Tie Me Down : Inhibiting RNA Polymerase. / Sousa, Rui J.

In: Cell, Vol. 135, No. 2, 17.10.2008, p. 205-207.

Research output: Contribution to journalArticle

Sousa, Rui J. / Tie Me Up, Tie Me Down : Inhibiting RNA Polymerase. In: Cell. 2008 ; Vol. 135, No. 2. pp. 205-207.
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