Thyroxine '-deiodination in brown adipose tissue and pineal gland: Implications for thermogenic regulation and role of melatonin

Manuel Puig-Domingo, Juan M. Guerrero, Russel J. Reiter, Michael J. Tannenbaum, Edward C. Hurlbut, Aldo Gonzalez-Briton, Celsa Santana

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

T4 type II '-deiodinase ('-D II) activity was studied in wild-captured Richardson's ground squirrels. As previously reported for other species, '-D II activity was detected in frontal cortex, cerebellum, pineal gland, and brown adipose tissue (BAT); in the median eminence the levels of '-D II activity were undetectable with our methodology. When pineal gland, frontal cortex, and cerebellum nyctohemeral profiles were studied, none of them showed variations. Cold exposure for 4 h led to an increase in the enzymatic activity 10-fold above the basal values for BAT, while in the pineal gland the values were doubled; cold exposure failed to change the '-D II activity in the frontal cortex. Acute melatonin treatment caused a 7-fold increase in '-D II activity in BAT, but did not affect enzyme activity in either the pineal gland or frontal cortex. The data indicate that '-D II in Richardson's ground squirrel shows classical localizations. Additionally, two new regulatory factors of '-D II are reported, i.e. melatonin for BAT and cold for the pineal gland.

Original languageEnglish (US)
Pages (from-to)677-680
Number of pages4
JournalEndocrinology
Volume123
Issue number2
DOIs
StatePublished - Aug 1 1988

ASJC Scopus subject areas

  • Endocrinology

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    Puig-Domingo, M., Guerrero, J. M., Reiter, R. J., Tannenbaum, M. J., Hurlbut, E. C., Gonzalez-Briton, A., & Santana, C. (1988). Thyroxine '-deiodination in brown adipose tissue and pineal gland: Implications for thermogenic regulation and role of melatonin. Endocrinology, 123(2), 677-680. https://doi.org/10.1210/endo-123-2-677