To the Editor: The report by Hirsh et al. in the March 19 issue,1 in which increased levels of coronary-sinus thromboxane B2 were demonstrated in patients with recent episodes of angina, supports previous experimental data showing increased thromboxane B2 levels in coronary-sinus blood of patients with exercise-induced angina2 and of patients with fixed obstructive coronary-artery disease in whom angina was induced by rapid atrial pacing.3 It is of broader potential importance that levels of thromboxane B2 in peripheral blood have been shown by several investigators to rise acutely during chest pain in patients known to have coronary-artery. . .
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