Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women

Anthony J. Borg, John R. Higgins, Shaun P. Brennecke, Eric K. Moses

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.

    Original languageEnglish (US)
    Pages (from-to)43-45
    Number of pages3
    JournalGynecologic and Obstetric Investigation
    Volume54
    Issue number1
    DOIs
    StatePublished - Oct 17 2002

    Keywords

    • Polymorphism
    • Pre-eclampsia
    • Thrombomodulin

    ASJC Scopus subject areas

    • Reproductive Medicine
    • Obstetrics and Gynecology

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