Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women

Anthony J. Borg; John R. Higgins; Shaun P. Brennecke; Eric K. Moses

doi:10.1159/000064696

Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women

Anthony J. Borg, John R. Higgins, Shaun P. Brennecke, Eric K. Moses

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.

Original language	English (US)
Pages (from-to)	43-45
Number of pages	3
Journal	Gynecologic and Obstetric Investigation
Volume	54
Issue number	1
DOIs	https://doi.org/10.1159/000064696
State	Published - Oct 17 2002

Keywords

Polymorphism
Pre-eclampsia
Thrombomodulin

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1159/000064696

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abstract = "Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.",

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AU - Moses, Eric K.

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AB - Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.

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Thrombomodulin Ala455Val dimorphism is not associated with pre-eclampsia in Australian and New Zealand women

Abstract

Keywords

ASJC Scopus subject areas

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