Abstract
Thrombomodulin plays an important role in thromboresistance. A common mutation of the gene at amino acid 455 producing valine instead of alanine has been implicated as being a risk factor in myocardial infarction and chronic heart disease. However, its link with pre-eclampsia remains controversial. This report explores the Ala455Val point mutation in 280 women as a predictor of pre-eclampsia with the conclusion that in this regard, the dimorphism is essentially neutral.
Original language | English (US) |
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Pages (from-to) | 43-45 |
Number of pages | 3 |
Journal | Gynecologic and Obstetric Investigation |
Volume | 54 |
Issue number | 1 |
DOIs | |
State | Published - Oct 17 2002 |
Keywords
- Polymorphism
- Pre-eclampsia
- Thrombomodulin
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology