Thirty-day complication rates do not differ by race among patients undergoing pancreaticoduodenectomy for pancreatic adenocarcinoma

Anastasios T. Mitsakos, Samuel O. Dennis, Alexander A. Parikh, Rebecca A. Snyder

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background and Objectives: Black patients with pancreatic ductal adenocarcinoma (PDAC) are less likely to receive multimodality treatment and have worse survival compared to White patients. However, little is known regarding racial differences in postoperative outcomes. The primary aim of this study was to determine if 30-day complication rates following pancreaticoduodenectomy (PD) differ by race. Methods: A retrospective cohort study of patients who underwent PD for PDAC from 2014 to 2016 within the ACS-NSQIP pancreatectomy-specific data set was performed. Primary outcomes were 30-day pancreas-specific and overall major complications. Results: A total of 6936 patients were identified, including 91.4% (N = 6337) White and 8.6% (N = 599) Black. Pathologic stage and rates of neoadjuvant therapy were similar among Whites and Blacks. Rates of pancreas-specific (23.9% vs. 23.1%, p =.88) and major postoperative complications (39.2% vs. 39.9%, p =.55) were similar between Whites and Blacks. By multivariable regression analysis, there was no association between race and odds of pancreas-specific complications (odds ratio [OR] 1.10, 95% confidence interval [CI] 0.89–1.37) or overall major complications (OR 1.13, 95% CI 0.95–1.36). Conclusions: Among patients undergoing PD for PDAC, Black race is not associated with increased pancreas-specific or overall 30-day postoperative complications. Short-term postoperative outcomes do not appear to explain the increase in pancreatic cancer mortality among Black patients.

Original languageEnglish (US)
Pages (from-to)970-977
Number of pages8
JournalJournal of Surgical Oncology
Issue number4
StatePublished - Mar 15 2021
Externally publishedYes


  • pancreatic adenocarcinoma
  • pancreaticoduodenectomy
  • postoperative complications
  • racial disparities

ASJC Scopus subject areas

  • Oncology
  • Surgery


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