Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

Viviana I. Pérez, Lisa A. Cortez, Christie M. Lew, Marisela Rodriguez, Celeste R. Webb, Holly Van Remmen, Asish Chaudhuri, Wenbo Qi, Shuko Lee, Alex Bokov, Wilson Fok, Dean Jones, Arlan Richardson, Junji Yodoi, Yiqiang Zhang, Kaoru Tominaga, Gene B. Hubbard, Yuji Ikeno

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1) +/0]. The Tg(TRX1) +/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1) +/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1) +/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1) +/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1) +/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.

Original languageEnglish (US)
Pages (from-to)1286-1299
Number of pages14
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume66 A
Issue number12
DOIs
StatePublished - Dec 2011

Keywords

  • Aging
  • Oxidative stress
  • Protein carbonylation
  • Thioredoxin
  • Transgenic mouse

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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