Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

Viviana I. Pérez; Lisa A. Cortez; Christie M. Lew; Marisela Rodriguez; Celeste R. Webb; Holly Van Remmen; Asish Chaudhuri; Wenbo Qi; Shuko Lee; Alex Bokov; Wilson Fok; Dean Jones; Arlan Richardson; Junji Yodoi; Yiqiang Zhang; Kaoru Tominaga; Gene B. Hubbard; Yuji Ikeno

doi:10.1093/gerona/glr125

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

Viviana I. Pérez, Lisa A. Cortez, Christie M. Lew, Marisela Rodriguez, Celeste R. Webb, Holly Van Remmen, Asish Chaudhuri, Wenbo Qi, Shuko Lee, Alex Bokov, Wilson Fok, Dean Jones, Arlan Richardson, Junji Yodoi, Yiqiang Zhang, Kaoru Tominaga, Gene B. Hubbard, Yuji Ikeno

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67 Scopus citations

Abstract

We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1) ^+/0]. The Tg(TRX1) ^+/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1) ^+/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1) ^+/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1) ^+/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1) ^+/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.

Original language	English (US)
Pages (from-to)	1286-1299
Number of pages	14
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	66 A
Issue number	12
DOIs	https://doi.org/10.1093/gerona/glr125
State	Published - Dec 2011

Keywords

Aging
Oxidative stress
Protein carbonylation
Thioredoxin
Transgenic mouse

ASJC Scopus subject areas

General Medicine

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10.1093/gerona/glr125

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Pérez, V. I., Cortez, L. A., Lew, C. M., Rodriguez, M., Webb, C. R., Van Remmen, H., Chaudhuri, A., Qi, W., Lee, S., Bokov, A., Fok, W., Jones, D., Richardson, A., Yodoi, J., Zhang, Y., Tominaga, K., Hubbard, G. B., & Ikeno, Y. (2011). Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 66 A(12), 1286-1299. https://doi.org/10.1093/gerona/glr125

Pérez, VI, Cortez, LA, Lew, CM, Rodriguez, M, Webb, CR, Van Remmen, H, Chaudhuri, A, Qi, W, Lee, S, Bokov, A, Fok, W, Jones, D, Richardson, A, Yodoi, J, Zhang, Y, Tominaga, K, Hubbard, GB & Ikeno, Y 2011, 'Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 66 A, no. 12, pp. 1286-1299. https://doi.org/10.1093/gerona/glr125

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title = "Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice",

abstract = "We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1) +/0]. The Tg(TRX1) +/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1) +/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1) +/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1) +/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1) +/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.",

keywords = "Aging, Oxidative stress, Protein carbonylation, Thioredoxin, Transgenic mouse",

author = "P{\'e}rez, {Viviana I.} and Cortez, {Lisa A.} and Lew, {Christie M.} and Marisela Rodriguez and Webb, {Celeste R.} and {Van Remmen}, Holly and Asish Chaudhuri and Wenbo Qi and Shuko Lee and Alex Bokov and Wilson Fok and Dean Jones and Arlan Richardson and Junji Yodoi and Yiqiang Zhang and Kaoru Tominaga and Hubbard, {Gene B.} and Yuji Ikeno",

note = "Funding Information: This research was supported by VA Merit Review Grant from the Department of Veteran Affairs (Y.I.), National Institutes of Health Grant AG13319 (Y.I.), The American Federation for Aging Research grant (Y.I.), and Grant from Glenn Foundation (Y.I.).",

year = "2011",

month = dec,

doi = "10.1093/gerona/glr125",

language = "English (US)",

volume = "66 A",

pages = "1286--1299",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

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number = "12",

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T1 - Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

AU - Pérez, Viviana I.

AU - Cortez, Lisa A.

AU - Lew, Christie M.

AU - Rodriguez, Marisela

AU - Webb, Celeste R.

AU - Van Remmen, Holly

AU - Chaudhuri, Asish

AU - Qi, Wenbo

AU - Lee, Shuko

AU - Bokov, Alex

AU - Fok, Wilson

AU - Jones, Dean

AU - Richardson, Arlan

AU - Yodoi, Junji

AU - Zhang, Yiqiang

AU - Tominaga, Kaoru

AU - Hubbard, Gene B.

AU - Ikeno, Yuji

N1 - Funding Information: This research was supported by VA Merit Review Grant from the Department of Veteran Affairs (Y.I.), National Institutes of Health Grant AG13319 (Y.I.), The American Federation for Aging Research grant (Y.I.), and Grant from Glenn Foundation (Y.I.).

PY - 2011/12

Y1 - 2011/12

N2 - We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1) +/0]. The Tg(TRX1) +/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1) +/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1) +/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1) +/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1) +/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.

AB - We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1) +/0]. The Tg(TRX1) +/0 mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1) +/0 mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1) +/0 mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1) +/0 mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1) +/0 mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.

KW - Aging

KW - Oxidative stress

KW - Protein carbonylation

KW - Thioredoxin

KW - Transgenic mouse

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JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 12

ER -

Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice

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Keywords

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