Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans

D. L. Kellogg, S. R. Morris, S. B. Rodriguez, Y. Liu, M. Grossmann, G. Stagni, A. M.M. Shepherd

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

During dynamic exercise in the heat, increases in skin blood flow are attenuated in hypertensive subjects when compared with normotensive subjects. We studied responses to passive heat stress (water-perfused suits) in eight hypertensive and eight normotensive subjects, Forearm blood flow was measured by venous-occlusion plethysmography, mean arterial pressure (MAP) was measured by Finapres, and forearm vascular conductance (FVC) was calculated. Bretylium tosylate (BT) iontophoresis was used to block active vasoconstriction in a small area of skin. Skin blood flow was indexed by laser-Doppler flowmetry at BT-treated and untreated sites, and cutaneous vascular conductance was calculated. In normothermia, FVC was lower in hypertensive than in normotensive subjects (P < 0.01). During heat stress, FVC rose to similar levels in both groups (P > 0.80); concurrent cutaneous vascular conductance increases were unaffected by BT treatment (P > 0.60). MAP was greater in hypertensive than in normotensive subjects during normothermia (P < 0.05, hypertensive vs. normotensive subjects). During hyperthermia, MAP fell in hypertensive subjects but showed no statistically significant change in normotensive subjects (P < 0.05, hypertensive vs. normotensive subjects). The internal temperature at which vasodilation began did not differ between groups (P > 0.80). FVC is reduced during normothermia in unmedicated hypertensive subjects; however, they respond to passive heat stress in a fashion no different from normotensive subjects.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalJournal of applied physiology
Volume85
Issue number1
StatePublished - Jul 1 1998

Keywords

  • Laser-Doppler flowmetry
  • Thermoregulation
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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