Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans

Dean L Kellogg Jr, S. R. Morris, S. B. Rodriguez, Y. Liu, M. Grossmann, G. Stagni, Alexander M Shepherd

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

During dynamic exercise in the heat, increases in skin blood flow are attenuated in hypertensive subjects when compared with normotensive subjects. We studied responses to passive heat stress (water-perfused suits) in eight hypertensive and eight normotensive subjects, Forearm blood flow was measured by venous-occlusion plethysmography, mean arterial pressure (MAP) was measured by Finapres, and forearm vascular conductance (FVC) was calculated. Bretylium tosylate (BT) iontophoresis was used to block active vasoconstriction in a small area of skin. Skin blood flow was indexed by laser-Doppler flowmetry at BT-treated and untreated sites, and cutaneous vascular conductance was calculated. In normothermia, FVC was lower in hypertensive than in normotensive subjects (P < 0.01). During heat stress, FVC rose to similar levels in both groups (P > 0.80); concurrent cutaneous vascular conductance increases were unaffected by BT treatment (P > 0.60). MAP was greater in hypertensive than in normotensive subjects during normothermia (P < 0.05, hypertensive vs. normotensive subjects). During hyperthermia, MAP fell in hypertensive subjects but showed no statistically significant change in normotensive subjects (P < 0.05, hypertensive vs. normotensive subjects). The internal temperature at which vasodilation began did not differ between groups (P > 0.80). FVC is reduced during normothermia in unmedicated hypertensive subjects; however, they respond to passive heat stress in a fashion no different from normotensive subjects.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalJournal of Applied Physiology
Volume85
Issue number1
StatePublished - Jul 1998

Fingerprint

Bretylium Tosylate
Vasodilation
Blood Vessels
Reflex
Forearm
Hot Temperature
Skin
Arterial Pressure
Iontophoresis
Laser-Doppler Flowmetry
Plethysmography
Vasoconstriction
Dehydration
Therapeutics

Keywords

  • Laser-Doppler flowmetry
  • Thermoregulation
  • Vasoconstriction

ASJC Scopus subject areas

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Kellogg Jr, D. L., Morris, S. R., Rodriguez, S. B., Liu, Y., Grossmann, M., Stagni, G., & Shepherd, A. M. (1998). Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans. Journal of Applied Physiology, 85(1), 175-180.

Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans. / Kellogg Jr, Dean L; Morris, S. R.; Rodriguez, S. B.; Liu, Y.; Grossmann, M.; Stagni, G.; Shepherd, Alexander M.

In: Journal of Applied Physiology, Vol. 85, No. 1, 07.1998, p. 175-180.

Research output: Contribution to journalArticle

Kellogg Jr, DL, Morris, SR, Rodriguez, SB, Liu, Y, Grossmann, M, Stagni, G & Shepherd, AM 1998, 'Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans', Journal of Applied Physiology, vol. 85, no. 1, pp. 175-180.
Kellogg Jr, Dean L ; Morris, S. R. ; Rodriguez, S. B. ; Liu, Y. ; Grossmann, M. ; Stagni, G. ; Shepherd, Alexander M. / Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans. In: Journal of Applied Physiology. 1998 ; Vol. 85, No. 1. pp. 175-180.
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