Thermogenic changes with chronic cold exposure in the naked mole-rat (Heterocephalus glaber)

Ryan Woodley, Rochelle Buffenstein

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The naked mole-rat (Heterocephalus glaber) lives communally in a thermally buffered underground habitat. Here, it relies primarily on ectothermic (behavioral) mechanisms to maintain body temperature (Tb). Outside this milieu, it is unable to effectively regulate Tb and Tb tracks that of ambient temperature (Ta). Although naked mole-rats, in their natural habitat have little need for cold-tolerance, we questioned whether or not thermogenic capacity would change with prolonged (>1 year) exposure to cooler conditions. We hypothesized that these rodents would not conform to common mammalian patterns and that non-shivering thermogenic (NST) capacity would be unchanged with chronic cold exposure. The capacity for NST was assessed following noradrenaline administration (0.8 mg/kg, s.c.) to lightly anesthetized (pentobarbital 6% m/v 40 mg/kg) animals and monitoring the concomitant changes in oxygen consumption and Tb. Results concur with the null hypothesis in that prolonged cold exposure did not elicit any increase in NST capacity (1.52±0.17 ml O2/g/h, cold-acclimated; 1.73±0.31 ml O2/g/h, control; P>0.05). Rapid heat loss across their uninsulated integument may necessitate continuous maximal stimulation of brown adipose tissue (BAT), and as such, prevent any further increase in thermogenic capacity following cold exposure.

Original languageEnglish (US)
Pages (from-to)827-834
Number of pages8
JournalComparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Volume133
Issue number3
DOIs
StatePublished - Nov 1 2002

Keywords

  • BAT
  • Cold-acclimation
  • Heterocephalus glaber
  • Metabolism
  • NST
  • Naked mole-rat
  • Non-shivering thermogenesis
  • Thermogenic capacity

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Molecular Biology

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