Therapeutic vascular systems

H. G. Clark, C. M. Agrawal, R. S. Stack

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The research program of Unit 1.2A, Therapeutic Vascular Systems, of the National Science Foundation/Engineering Research Center (NSF/ERC) is described. The unit's goal is to develop polymeric stents (stiffening elements) that can be implanted in a diseased artery simultaneously or sequentially to percutaneous transluminal coronary angioplasty (PTCA), and to make these stents in such a way that they will become encapsulated by tissue, degraded, and eventually absorbed. The unit produced stents from nylon, polyglycolic acid, and poly(L-lactic acid) and developed a method for in vitro evaluation of mechanical properties. A poly(L-lactic acid) stent has been placed in the femoral artery of a dog, and the vessel has remained patent for several months. In vitro testing of Vicryl (lactic/glycolic acid copolymer) stents show that they rapidly lose modulus due to plasticization by warm water, and nylon was also unsatisfactory, although better than Vicryl.

Original languageEnglish (US)
Title of host publicationBiomedical Engineering Perspectives
Subtitle of host publicationHealth Care Technologies for the 1990's and Beyond
PublisherPubl by IEEE
Number of pages2
Editionpt 2
ISBN (Print)0879425598
StatePublished - Dec 1 1990
EventProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Philadelphia, PA, USA
Duration: Nov 1 1990Nov 4 1990

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 2
ISSN (Print)0589-1019


OtherProceedings of the 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityPhiladelphia, PA, USA

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics


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