Therapeutic effect of infused fluosol-da/carbogen with ephedrine, flunarizine, or nitroprusside

Beverly A. Teicher, Sylvia A. Holden, David Northey, Mark W. Dewhirst, Terence S. Herman

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The perfluorochemical emulsion Fluosol-DA plus carbogen breathing has been shown to increase the effectiveness or radiation therapy in preclinical solid tumors when the emulsion was administered by i.v. bolus injection. Much of the enhancement in tumor radiation response was lost when the emulsion was administered slowly. Purpose: We hypothesized that an increase in tumor perfusion resulted when Fluosol-DA was administered rapidly. Methods and Materials: In the present study, the α/,β agonist ephedrine, the Ca2+ channel blocker flunarizine and the nitric oxide producing vasodilating drug nitroprusside have been tested. Results: Ephedrine administration resulted in a decrease in the radiation plus Fluosol-DA ± carbogen antitumor effects in both the Lewis lung carcinoma and FSaIIC tumor systems. In contrast, flunarizine administration resulted in an increase in the efficacy of the radiation plus carbogen and the radiation plus Fluosol-DA/carbogen in both tumor systems. Even with flunarizine administration Fluosol-DA delivered slowly was less effective than when the emulsion was given rapidly. Flunarizine with Fluosol-DA infused i.v. over 30 min followed by carbogen breathing prior to and during radiation therapy resulted in a 1.7-1.6-fold increase in response compared with 2.4-2.2-fold with Fluosol-DA administered by injection i.v. and carbogen breathing prior to and during radiation therapy using growth delay of the Lewis lung carcinoma. The effects of nitroprusside were complex. This drug had considerably more effect at 10 Gy than at higher radiation doses. Conclusion: These studies suggest that Fluosol-DA given by i.v. injection may increase tumor perfusion and that a drug like flunarizine may be beneficial if the Fluosol-DA is administered slowly followed by carbogen breathing and radiation therapy.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalInternational journal of radiation oncology, biology, physics
Volume26
Issue number1
DOIs
StatePublished - Apr 30 1993
Externally publishedYes

Keywords

  • Flunarizine
  • Fluosol-DA
  • Nitroprusside
  • Radiosensitization
  • Tumor perfusion

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint

Dive into the research topics of 'Therapeutic effect of infused fluosol-da/carbogen with ephedrine, flunarizine, or nitroprusside'. Together they form a unique fingerprint.

Cite this