Therapeutic and prophylactic efficacy of aminocandin (IP960) against disseminated candidiasis in mice

L. K. Najvar, R. Bocanegra, N. P. Wiederhold, C. Lambros, N. Najarian, T. F. Patterson, J. R. Graybill

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20 Scopus citations


Extended interval dosing of the echinocandins has been suggested as a potential strategy to overcome the need for daily intravenous administration. This study evaluated the therapeutic and prophylactic efficacy of single doses of aminocandin, a new echinocandin in preclinical development, in a murine model of invasive candidiasis. For therapy, groups of mice were infected with Candida albicans, followed by a single dose of aminocandin (1-15 mg/kg) or placebo (mannitol 5% w/ v) administered 1day after inoculation. As prophylaxis, mice were given a single dose (5 or 30 mg/kg) of aminocandin, caspofungin, or placebo at increasing intervals between dose and inoculation. In both treatment and prophylaxis studies, survival was assessed at 21 days post-inoculation. The reduction in fungal burden was assessed in kidney tissue on day 8 post-inoculation. For treatment, single doses of aminocandin of ≥2.5mg/kg prolonged survival significantly. In addition, the two doses evaluated for reductions in fungal burden (5 and 15 mg/kg) revealed fungicidal activity. As prophylaxis, both aminocandin and caspofungin 5 and 30 mg/kg prolonged survival when given 7 days before inoculation. Aminocandin and caspofungin 30 mg/kg were both able to prolong survival when the interval between dose and inoculation was increased to 10 days. When this interval was extended to 14 days, only aminocandin 30 mg/kg prolonged survival and reduced fungal burden. These results demonstrate that single doses of aminocandin are effective as treatment and prophylaxis, and suggest that extended interval dosing may be a useful strategy for treating invasive candidiasis.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalClinical Microbiology and Infection
Issue number6
StatePublished - Jun 2008


  • Aminocandin
  • Antifungal prophylaxis
  • Candida albicans
  • Extended interval dosing
  • Invasive candidiasis
  • Mouse model

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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