The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

André Brannvoll; Xiaoyu Xue; Youngho Kwon; Smaragdi Kompocholi; Anne Katrine W. Simonsen; Keerthana S. Viswalingam; Leticia Gonzalez; Ian D. Hickson; Vibe H. Oestergaard; Hocine W. Mankouri; Patrick Sung; Michael Lisby

doi:10.1016/j.celrep.2020.107849

The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

André Brannvoll, Xiaoyu Xue, Youngho Kwon, Smaragdi Kompocholi, Anne Katrine W. Simonsen, Keerthana S. Viswalingam, Leticia Gonzalez, Ian D. Hickson, Vibe H. Oestergaard, Hocine W. Mankouri, Patrick Sung, Michael Lisby

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

Original language	English (US)
Article number	107849
Journal	Cell Reports
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.celrep.2020.107849
State	Published - Jul 7 2020

Keywords

D-loop dissociation
DNA helicase
FANCD2
FANCJ
FANCM
Fanconi anemia
RAD51
homologous recombination
interstrand DNA crosslink repair
sister-chromatid exchange

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.107849

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Brannvoll, A., Xue, X., Kwon, Y., Kompocholi, S., Simonsen, A. K. W., Viswalingam, K. S., Gonzalez, L., Hickson, I. D., Oestergaard, V. H., Mankouri, H. W., Sung, P., & Lisby, M. (2020). The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells. Cell Reports, 32(1), Article 107849. https://doi.org/10.1016/j.celrep.2020.107849

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abstract = "DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.",

keywords = "D-loop dissociation, DNA helicase, FANCD2, FANCJ, FANCM, Fanconi anemia, RAD51, homologous recombination, interstrand DNA crosslink repair, sister-chromatid exchange",

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AU - Brannvoll, André

AU - Xue, Xiaoyu

AU - Kwon, Youngho

AU - Kompocholi, Smaragdi

AU - Simonsen, Anne Katrine W.

AU - Viswalingam, Keerthana S.

AU - Gonzalez, Leticia

AU - Hickson, Ian D.

AU - Oestergaard, Vibe H.

AU - Mankouri, Hocine W.

AU - Sung, Patrick

AU - Lisby, Michael

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AB - DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

KW - D-loop dissociation

KW - DNA helicase

KW - FANCD2

KW - FANCJ

KW - FANCM

KW - Fanconi anemia

KW - RAD51

KW - homologous recombination

KW - interstrand DNA crosslink repair

KW - sister-chromatid exchange

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The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

Abstract

Keywords

ASJC Scopus subject areas

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