The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells

André Brannvoll, Xiaoyu Xue, Youngho Kwon, Smaragdi Kompocholi, Anne Katrine W. Simonsen, Keerthana S. Viswalingam, Leticia Gonzalez, Ian D. Hickson, Vibe H. Oestergaard, Hocine W. Mankouri, Patrick Sung, Michael Lisby

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.

Original languageEnglish (US)
Article number107849
JournalCell Reports
Volume32
Issue number1
DOIs
StatePublished - Jul 7 2020

Keywords

  • D-loop dissociation
  • DNA helicase
  • FANCD2
  • FANCJ
  • FANCM
  • Fanconi anemia
  • RAD51
  • homologous recombination
  • interstrand DNA crosslink repair
  • sister-chromatid exchange

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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