@article{83f88e616d754526a0234d1960c1b8c1,
title = "The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells",
abstract = "DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.",
keywords = "D-loop dissociation, DNA helicase, FANCD2, FANCJ, FANCM, Fanconi anemia, RAD51, homologous recombination, interstrand DNA crosslink repair, sister-chromatid exchange",
author = "Andr{\'e} Brannvoll and Xiaoyu Xue and Youngho Kwon and Smaragdi Kompocholi and Simonsen, {Anne Katrine W.} and Viswalingam, {Keerthana S.} and Leticia Gonzalez and Hickson, {Ian D.} and Oestergaard, {Vibe H.} and Mankouri, {Hocine W.} and Patrick Sung and Michael Lisby",
note = "Funding Information: This work was supported by the Danish Council for Independent Research (FSS) and the Villum Foundation to A.K.W.S. and M.L.; the Danish National Research Foundation (DNRF115) to A.B., H.W.M., M.L., and I.D.H.; the Dagmar Marshall Foundation to A.B.; and the Novo Nordisk Foundation to K.S.V. and M.L. P.S. and X.X. were supported by National Institutes of Health grants R21 ES029513 and R21 ES028792 , and P.S. also received support from grant R35 CA241801 . We would like to thank Martin Cohn and Jakob Nilsson for sharing reagents and Julien Duxin for comments on the manuscript. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jul,
day = "7",
doi = "10.1016/j.celrep.2020.107849",
language = "English (US)",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}