@article{83f88e616d754526a0234d1960c1b8c1,
title = "The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells",
abstract = "DNA helicases are important for DNA repair processes. Here, Brannvoll et al. show that ZGRF1 is a 5′-to-3′ DNA helicase that promotes the resolution of replication-blocking DNA lesions by homologous recombination. ZGRF1 is recruited to sites of DNA damage and directly stimulates the RAD51 recombinase.",
keywords = "D-loop dissociation, DNA helicase, FANCD2, FANCJ, FANCM, Fanconi anemia, RAD51, homologous recombination, interstrand DNA crosslink repair, sister-chromatid exchange",
author = "Andr{\'e} Brannvoll and Xiaoyu Xue and Youngho Kwon and Smaragdi Kompocholi and Simonsen, {Anne Katrine W.} and Viswalingam, {Keerthana S.} and Leticia Gonzalez and Hickson, {Ian D.} and Oestergaard, {Vibe H.} and Mankouri, {Hocine W.} and Patrick Sung and Michael Lisby",
note = "Funding Information: This work was supported by the Danish Council for Independent Research (FSS) and the Villum Foundation to A.K.W.S. and M.L.; the Danish National Research Foundation (DNRF115) to A.B., H.W.M., M.L., and I.D.H.; the Dagmar Marshall Foundation to A.B.; and the Novo Nordisk Foundation to K.S.V. and M.L. P.S. and X.X. were supported by National Institutes of Health grants R21 ES029513 and R21 ES028792 , and P.S. also received support from grant R35 CA241801 . We would like to thank Martin Cohn and Jakob Nilsson for sharing reagents and Julien Duxin for comments on the manuscript. Funding Information: This work was supported by the Danish Council for Independent Research (FSS) and the Villum Foundation to A.K.W.S. and M.L.; the Danish National Research Foundation (DNRF115) to A.B. H.W.M. M.L. and I.D.H.; the Dagmar Marshall Foundation to A.B.; and the Novo Nordisk Foundation to K.S.V. and M.L. P.S. and X.X. were supported by National Institutes of Health grants R21 ES029513 and R21 ES028792, and P.S. also received support from grant R35 CA241801. We would like to thank Martin Cohn and Jakob Nilsson for sharing reagents and Julien Duxin for comments on the manuscript. M.L. and P.S. conceived the project. A.B. and X.X. designed experiments with supervision from M.L. P.S. H.W.M. V.H.O. and I.D.H. A.B. and X.X. performed experiments with assistance from S.K. K.S.V. Y.K. L.G. and A.K.W.S. A.B. K.S.V. S.K. and X.X. performed analysis with assistance from A.K.W.S. A.B. M.L. X.X. and P.S. wrote the manuscript, and all authors edited it. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = jul,
day = "7",
doi = "10.1016/j.celrep.2020.107849",
language = "English (US)",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}