The vulnerability/stress model of schizophrenic relapse: a longitudinal study

K. H. Nuechterlein, M. E. Dawson, J. Ventura, M. Gitlin, K. L. Subotnik, K. S. Snyder, J. Mintz, G. Bartzokis

Research output: Contribution to journalArticlepeer-review

168 Scopus citations


A tentative model for conceptualizing the interplay of vulnerability factors, stressors, and protective factors in the course of schizophrenia is discussed. A study of the initial years after a first schizophrenic episode is testing the predictive role of key factors. During an initial 1‐year period of depot antipsychotic medication, independent life events and expressed emotion were found to predict the likelihood of psychotic relapse. Initial analyses indicate that independent life events play less of a role in relapse prediction during a medication‐free period. These results suggest that maintenance antipsychotic medication raises the threshold for return of psychotic symptoms, such that relapses are less likely unless major environmental stressors occur. A low expressed emotion environment may be a protective factor.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalActa Psychiatrica Scandinavica
StatePublished - Sep 1994
Externally publishedYes


  • antipsychotic medication
  • relapse
  • schizophrenia
  • stress
  • vulnerability

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'The vulnerability/stress model of schizophrenic relapse: a longitudinal study'. Together they form a unique fingerprint.

Cite this