The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals

F. Yang, K. H. Naberhaus, G. S. Adrian, J. M. Gardella, J. E. Brissenden, B. H. Bowman

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Characterization of the 5′-flanking region of the DBP genomic sequence is reported. Nucleotide sequences that serve as cis-regulatory elements for transcription in other genes have been found and include metal regulatory elements, viral enhancers, adipocyte and mitotic signals. The promoter region of DBP is not homologous to the 5′-flanking region of the albumin and α-fetoprotein genes despite the strong protein homology and evolutionary relationship among the three proteins.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalGene
Volume54
Issue number2-3
DOIs
StatePublished - 1987

Keywords

  • cis-regulatory elements
  • Group-specific component
  • metallothionein
  • plasma proteins
  • promoter
  • recombinant DNA
  • λ Charon vector

ASJC Scopus subject areas

  • Genetics

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