The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals

F. Yang; K. H. Naberhaus; G. S. Adrian; J. M. Gardella; J. E. Brissenden; B. H. Bowman

doi:10.1016/0378-1119(87)90499-9

The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals

F. Yang, K. H. Naberhaus, G. S. Adrian, J. M. Gardella, J. E. Brissenden, B. H. Bowman

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Characterization of the 5′-flanking region of the DBP genomic sequence is reported. Nucleotide sequences that serve as cis-regulatory elements for transcription in other genes have been found and include metal regulatory elements, viral enhancers, adipocyte and mitotic signals. The promoter region of DBP is not homologous to the 5′-flanking region of the albumin and α-fetoprotein genes despite the strong protein homology and evolutionary relationship among the three proteins.

Original language	English (US)
Pages (from-to)	285-290
Number of pages	6
Journal	Gene
Volume	54
Issue number	2-3
DOIs	https://doi.org/10.1016/0378-1119(87)90499-9
State	Published - 1987

Keywords

cis-regulatory elements
Group-specific component
metallothionein
plasma proteins
promoter
recombinant DNA
λ Charon vector

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(87)90499-9

Cite this

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title = "The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals",

abstract = "Characterization of the 5′-flanking region of the DBP genomic sequence is reported. Nucleotide sequences that serve as cis-regulatory elements for transcription in other genes have been found and include metal regulatory elements, viral enhancers, adipocyte and mitotic signals. The promoter region of DBP is not homologous to the 5′-flanking region of the albumin and α-fetoprotein genes despite the strong protein homology and evolutionary relationship among the three proteins.",

keywords = "cis-regulatory elements, Group-specific component, metallothionein, plasma proteins, promoter, recombinant DNA, λ Charon vector",

author = "F. Yang and Naberhaus, {K. H.} and Adrian, {G. S.} and Gardella, {J. M.} and Brissenden, {J. E.} and Bowman, {B. H.}",

note = "Funding Information: We thank Betty Russell for manuscript preparation. This research was supported by NIH grant GM33298, grant CD-303-A of the American Cancer Society and grant 86-G-371 from the American Heart Association, Texas Affiliate.",

year = "1987",

doi = "10.1016/0378-1119(87)90499-9",

language = "English (US)",

volume = "54",

pages = "285--290",

journal = "Gene",

issn = "0378-1119",

publisher = "Elsevier",

number = "2-3",

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TY - JOUR

T1 - The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals

AU - Yang, F.

AU - Naberhaus, K. H.

AU - Adrian, G. S.

AU - Gardella, J. M.

AU - Brissenden, J. E.

AU - Bowman, B. H.

N1 - Funding Information: We thank Betty Russell for manuscript preparation. This research was supported by NIH grant GM33298, grant CD-303-A of the American Cancer Society and grant 86-G-371 from the American Heart Association, Texas Affiliate.

PY - 1987

Y1 - 1987

N2 - Characterization of the 5′-flanking region of the DBP genomic sequence is reported. Nucleotide sequences that serve as cis-regulatory elements for transcription in other genes have been found and include metal regulatory elements, viral enhancers, adipocyte and mitotic signals. The promoter region of DBP is not homologous to the 5′-flanking region of the albumin and α-fetoprotein genes despite the strong protein homology and evolutionary relationship among the three proteins.

AB - Characterization of the 5′-flanking region of the DBP genomic sequence is reported. Nucleotide sequences that serve as cis-regulatory elements for transcription in other genes have been found and include metal regulatory elements, viral enhancers, adipocyte and mitotic signals. The promoter region of DBP is not homologous to the 5′-flanking region of the albumin and α-fetoprotein genes despite the strong protein homology and evolutionary relationship among the three proteins.

KW - cis-regulatory elements

KW - Group-specific component

KW - metallothionein

KW - plasma proteins

KW - promoter

KW - recombinant DNA

KW - λ Charon vector

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DO - 10.1016/0378-1119(87)90499-9

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AN - SCOPUS:0023275733

VL - 54

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EP - 290

JO - Gene

JF - Gene

SN - 0378-1119

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ER -

The vitamin D-binding protein gene contains conserved nucleotide sequences that respond to heavy metal, adipocyte and mitotic signals

Abstract

Keywords

ASJC Scopus subject areas

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