The vertebrate phototransduction cascade: Amplification and termination mechanisms

Research output: Contribution to journalReview articlepeer-review

43 Scopus citations

Abstract

The biochemical cascade which transduces light into a neuronal signal in retinal photoreceptors is a heterotrimeric GTP-binding protein (G protein) signaling pathway called phototransduction. Works from psychophysicists, electrophysiologists, biochemists, and geneticists over several decades have come together to shape our understanding of how photon absorption leads to photoreceptor membrane hyperpolarization. The insights of phototransduction provide the foundation for a mechanistic account of signaling from many other G protein-coupled receptors (GPCR) found throughout nature. The application of reverse genetic techniques has strengthened many historic findings and helped to describe this pathway at greater molecular details. However, many important questions remain to be answered.

Original languageEnglish (US)
Pages (from-to)101-121
Number of pages21
JournalErgebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie
Volume154
DOIs
StatePublished - 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Pharmacology
  • Physiology (medical)

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