The Versatile Attributes of MGMT: Its Repair Mechanism, Crosstalk with Other DNA Repair Pathways, and Its Role in Cancer

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

O6-methylguanine-DNA methyltransferase (MGMT or AGT) is a DNA repair protein with the capability to remove alkyl groups from O6-AlkylG adducts. Moreover, MGMT plays a crucial role in repairing DNA damage induced by methylating agents like temozolomide and chloroethylating agents such as carmustine, and thereby contributes to chemotherapeutic resistance when these agents are used. This review delves into the structural roles and repair mechanisms of MGMT, with emphasis on the potential structural and functional roles of the N-terminal domain of MGMT. It also explores the development of cancer therapeutic strategies that target MGMT. Finally, it discusses the intriguing crosstalk between MGMT and other DNA repair pathways.

Original languageEnglish (US)
Article number331
JournalCancers
Volume16
Issue number2
DOIs
StatePublished - Jan 2024

Keywords

  • AGT
  • MGMT
  • base excision repair (BER)
  • direct reversal
  • homologous recombination (HR)
  • mismatch repair (MMR)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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