The utility of Bayesian model averaging for detecting known oligogenic effects.

L. J. Martin, A. G. Comuzzie, K. E. North, J. T. Williams, J. Blangero

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    In this paper we examine the utility of the Bayesian model averaging approach proposed by Blangero et al. [Genet Epidemiol 17(Suppl. 1):S67-72, 1999] for the detection of known oligogenic effects on quantitative trait 1 (Q1) in the simulated Genetic Analysis Workshop 12 data. The results were consistent with the underlying genetic model: two major QTLs were identified on chromosomes 19 and 2, with heritabilities of 17% and 20%, respectively, located near the position of major genes 1 and 2.

    Original languageEnglish (US)
    Pages (from-to)S789-793
    JournalGenetic epidemiology
    Volume21 Suppl 1
    DOIs
    StatePublished - 2001

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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