The use of microfabricated probes to penetrate the internal elastic lamina and intimal hyperplasia

J. R. Kneller, C. C. Wu, D. A. Vorp, M. L. Reed, L. E. Weiss, H. S. Borovetz, S. Watkins, M. D. Feldman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The local administration of drug or gene therapy to inhibit restenosis is currently limited by the internal elastic lamina and atherosclerotic plaque. Microprobes fabricated with micro electrical mechanical systems (MEMS) technology offers the potential for effective delivery of high concentrations of therapeutics through these barriers. However, excessive trauma in penetrating these barriers will enhance restenosis. Accordingly, we examined the importance of microprobe tip sharpness versus height in transecting the IEL and hyperplastic intima. Three groups of microprobes were examined: 65 ± 15 and 140 ± 20 μm tall sharp, and 185 ± 25 μm tall blunt microprobes. Data was collected from 94 microprobes in normal and 46 microprobes in atherosclerotic rabbit iliac arteries. In normal vessels, the 140 ± 20 μm sharp microprobes all transected the IEL and did so by maintaining the transected edges adjacent to the microprobe tip minimizing vascular damage. Few 185 ± 25 μm blunt microprobes transfected the IEL, but when they did, the edges were snapped well beyond the microprobe tip. All microprobes compressed the hyperplastic intima, but were not tall enough to gain entrance to the media. A novel approach to penetrate the barriers to delivery of drug and gene therapy utilizing MEMS technology is presented. Microprobe tip sharpness and associated radial stress application are more important than height. Future microprobes will have to be taller to reach the media in arteries with atherosclerosis.

Original languageEnglish (US)
Pages (from-to)37-50
Number of pages14
JournalJournal of Cardiovascular Diagnosis and Procedures
Volume16
Issue number2
StatePublished - Dec 1 1999

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'The use of microfabricated probes to penetrate the internal elastic lamina and intimal hyperplasia'. Together they form a unique fingerprint.

Cite this