The use of methotrexate perioperatively in patients with rheumatoid arthritis undergoing major joint replacement surgery: Will we ever have consensus about its use?

Graciela S. Alarcón, Larry W. Moreland, Kenneth Jaffe, R. Macon Phillips, Tomas Bocanegra, I. Jon Russell

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Whether methotrexate can be safely administered during the perioperative period to rheumatoid arthritis patients undergoing arthroplasties is an issue that has not been resolved to date. We are describing our attempt to conduct a case-controlled, multicenter study addressing this issue. The estimated sample size of approximately 140 patients proved to be difficult to recruit. Complications were all mild, but there tended to be more perioperative complications in the methotrexate-treated than in the placebo-treated patients. Possible explanations for the failure to complete the study are discussed.

Original languageEnglish (US)
Pages (from-to)6-8
Number of pages3
JournalJournal of Clinical Rheumatology
Volume2
Issue number1
DOIs
StatePublished - Feb 1996
Externally publishedYes

Keywords

  • Arthroplasty
  • Methotrexate
  • Perioperative period
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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