The use of iohexol in patients with previous reactions to ionic contrast material: A multicenter clinical trial

Robert L. Siegle, Robert A. Halvorsen, James Dillon, Morris L. Gavant, Elkan Halpern

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Patients who have had prior reactions to iodinated contrast material have increased risk for repeat reactions. Nonionic contrast agents have been reported to reduce the risk of contrast reactions. A multicenter study was undertaken to determine the repeat reaction rate using iohexol. Two hundred ninety-one repeat reactors were included in the study, of whom one-third received premedication. Sixteen patients (5.5%) experienced repeat reactions; none was severe, and only one was more serious than the prior reaction. This is in contrast to the reported 16% to 44% repeated reaction rate for ionic agents. We conclude that iohexol is effective in reducing the occurrence of repeat reactions from the level observed with ionic agents without premedication. Iohexol appears to be as effective as ionic agents plus premedication in this high-risk group of Patients.

Original languageEnglish (US)
Pages (from-to)411-416
Number of pages6
JournalInvestigative Radiology
Volume26
Issue number5
DOIs
StatePublished - May 1991

Keywords

  • Contrast material reactions
  • Nonionic contrast material
  • Prior contrast reactors

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'The use of iohexol in patients with previous reactions to ionic contrast material: A multicenter clinical trial'. Together they form a unique fingerprint.

Cite this