The use of clozapine among individuals with intellectual disability: A review

Ashvind N. Singh, Johnny L. Matson, B. D. Hill, Russell D. Pella, Christopher L. Cooper, Angela D. Adkins

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


Clozapine has been approved in the United States since 1990 for refractory or treatment resistant schizophrenia in the general population. However, as with many other antipsychotic medications, it is being prescribed for reasons other than those indicated. Among individuals with intellectual disabilities, clozapine is increasingly being prescribed to treat behavioral problems, although the empirical evidence for such a practice is lacking. This review was undertaken as an attempt to summarize the available studies regarding the use of clozapine for behavioral purposes among individuals with intellectual disabilities. Findings of our review suggest that the effectiveness of clozapine in targeting challenging behaviors among individuals with intellectual disabilities is relatively inconclusive at present. We discuss reasons why these limitations exist and offer some solutions to help alleviate these limitations.

Original languageEnglish (US)
Pages (from-to)1135-1141
Number of pages7
JournalResearch in Developmental Disabilities
Issue number6
StatePublished - Nov 1 2010


  • Behavior problems
  • Clozapine
  • Intellectual disabilities
  • Medication
  • Treatment

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology


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