The Use of Aspirin in Ischemic Heart Disease

Jane F. Desforges, John E. Willard, Richard A. Lange, L. David Hillis

Research output: Contribution to journalReview articlepeer-review

146 Scopus citations


WITHIN a decade of the isolation of salicylate in 1892, aspirin was introduced as an analgesic and antipyretic agent. In 1971, Vane described its inhibition of prostaglandin synthesis from arachidonate in homogenates of guinea pig lung,1 and Smith and Willis demonstrated that aspirin blocks the production of prostaglandin in human platelets.2 During the past decade, it has been shown that platelet aggregation and the formation of thrombi are pathophysiologically important in syndromes of ischemic heart disease. As a result, aspirin is widely used in patients with ischemic heart disease, and its use has recently been advocated in subjects without clinically…

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalNew England Journal of Medicine
Issue number3
StatePublished - Jul 16 1992
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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