The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio as a predictor of insulin resistance, β-cell function, and diabetes in Hispanics and African Americans

Kendra A. Young, Amita Maturu, Carlos Lorenzo, Carl D. Langefeld, Lynne E. Wagenknecht, Yii Der I. Chen, Kent D. Taylor, Jerome I. Rotter, Jill M. Norris, Neda Rasouli

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective: The TG/HDL-C ratio is used as a marker of insulin resistance (IR) in Caucasians; however, there is limited data in other ethnic groups. We hypothesized that the TG/HDL-C ratio is associated with IR in Hispanics and African Americans (AA). Research design and methods: Data from the Insulin Resistance Atherosclerosis Family Study was examined for associations between TG/HDL-C ratio and IR, β-cell function and incident diabetes in non-diabetic Hispanics (n = 872, 63% female) and AA (n = 371, 61% female). Insulin sensitivity index (SI) and disposition index (DI) from frequently-sampled intravenous glucose tolerance tests were used as markers of IR and β-cell function respectively. Incident type 2 diabetes was determined by fasting glucose ≥ 126 mg/dl or initiation of anti-hyperglycemia agents over 5 year follow-up. Results: Higher TG/HDL-C ratio was associated with IR in Hispanic and AA men and women (P < 0.0002), as well as β-cell function in Hispanic women and AA men and women (P < 0.02). TG/HDL-C predicted incident type 2 diabetes in women (area under the curves 0.703 and 0.795 for Hispanics and AA respectively). Conclusions: Similar to Caucasians, the TG/HDL-C ratio can be used to identify IR in Hispanics and AA, and may predict type 2 diabetes in women.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalJournal of Diabetes and Its Complications
Volume33
Issue number2
DOIs
StatePublished - Feb 2019

Keywords

  • African Americans
  • Beta-cell function
  • Hispanics
  • Insulin resistance
  • TG/HDL-C ratio
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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