The transfer of cocaine and its metabolites across the term human placenta

Steven Schenker, Yiqian Yang, Raymond F. Johnson, John W. Downing, Robert S Schenken, George I. Henderson, Thomas S King

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

This study defines human placental transport of cocaine and its two minor, but pharmacologically active, metabolites - norcocaine and cocaethylene. The experimental system was the single, isolated perfused cotyledon of a normal term human placenta, and antipyrine served as a freely diffusible marker. Cocaine was transferred rapidly by the placenta at a rate about 80% that of antipyrine. The transfer had characteristics of passive transport consistent with the high lipid solubility of the drug. We found no evidence of significant placental metabolism of cocaine during its rapid placental transfer. Ethanol did not alter the cocaine transfer rate. Norcocaine and cocaethylene were equally as rapidly transferred. Thus the placenta is no barrier to the transfer of cocaine and its derivatives to the fetus.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalClinical Pharmacology and Therapeutics
Volume53
Issue number3
StatePublished - Mar 1993

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Cocaine
Placenta
Antipyrine
Cotyledon
Solubility
Fetus
Ethanol
Lipids
Pharmaceutical Preparations
cocaethylene
norcocaine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Schenker, S., Yang, Y., Johnson, R. F., Downing, J. W., Schenken, R. S., Henderson, G. I., & King, T. S. (1993). The transfer of cocaine and its metabolites across the term human placenta. Clinical Pharmacology and Therapeutics, 53(3), 329-339.

The transfer of cocaine and its metabolites across the term human placenta. / Schenker, Steven; Yang, Yiqian; Johnson, Raymond F.; Downing, John W.; Schenken, Robert S; Henderson, George I.; King, Thomas S.

In: Clinical Pharmacology and Therapeutics, Vol. 53, No. 3, 03.1993, p. 329-339.

Research output: Contribution to journalArticle

Schenker, S, Yang, Y, Johnson, RF, Downing, JW, Schenken, RS, Henderson, GI & King, TS 1993, 'The transfer of cocaine and its metabolites across the term human placenta', Clinical Pharmacology and Therapeutics, vol. 53, no. 3, pp. 329-339.
Schenker S, Yang Y, Johnson RF, Downing JW, Schenken RS, Henderson GI et al. The transfer of cocaine and its metabolites across the term human placenta. Clinical Pharmacology and Therapeutics. 1993 Mar;53(3):329-339.
Schenker, Steven ; Yang, Yiqian ; Johnson, Raymond F. ; Downing, John W. ; Schenken, Robert S ; Henderson, George I. ; King, Thomas S. / The transfer of cocaine and its metabolites across the term human placenta. In: Clinical Pharmacology and Therapeutics. 1993 ; Vol. 53, No. 3. pp. 329-339.
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