TY - JOUR
T1 - The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study
T2 - Design, recruitment, and initial examination
AU - Splansky, Greta Lee
AU - Corey, Diane
AU - Yang, Qiong
AU - Atwood, Larry D.
AU - Cupples, L. Adrienne
AU - Benjamin, Emelia J.
AU - D'Agostino, Ralph B.
AU - Fox, Caroline S.
AU - Larson, Martin G.
AU - Murabito, Joanne M.
AU - O'Donnell, Christopher J.
AU - Vasan, Ramachandran S.
AU - Wolf, Philip A.
AU - Levy, Daniel
PY - 2007/6
Y1 - 2007/6
N2 - For nearly 60 years, the Framingham Heart Study has examined the natural history, risk factors, and prognosis of cardiovascular, lung, and other diseases. Recruitment of the Original Cohort began in 1948. Twenty-three years later, 3,548 children of the Original Cohort, along with 1,576 of their spouses, enrolled in the Offspring Cohort. Beginning in 2002, 4,095 adults having at least one parent in the Offspring Cohort enrolled in the Third Generation Cohort, along with 103 parents of Third Generation Cohort participants who were not previously enrolled in the Offspring Cohort. The objective of new recruitment was to complement phenotypic and genotypic information obtained from prior generations, with priority assigned to larger families. From a pool of 6,553 eligible individuals, 1,912 men and 2,183 women consented and attended the first examination (mean age: 40 (standard deviation: 9) years; range: 19-72 years). The examination included clinical and laboratory assessments of vascular risk factors and imaging for subclinical atherosclerosis, as well as assessment of cardiac structure and function. The comparison of Third Generation Cohort data with measures previously collected from the first two generations will facilitate investigations of genetic and environmental risk factors for subclinical and overt diseases, with a focus on cardiovascular and lung disorders.
AB - For nearly 60 years, the Framingham Heart Study has examined the natural history, risk factors, and prognosis of cardiovascular, lung, and other diseases. Recruitment of the Original Cohort began in 1948. Twenty-three years later, 3,548 children of the Original Cohort, along with 1,576 of their spouses, enrolled in the Offspring Cohort. Beginning in 2002, 4,095 adults having at least one parent in the Offspring Cohort enrolled in the Third Generation Cohort, along with 103 parents of Third Generation Cohort participants who were not previously enrolled in the Offspring Cohort. The objective of new recruitment was to complement phenotypic and genotypic information obtained from prior generations, with priority assigned to larger families. From a pool of 6,553 eligible individuals, 1,912 men and 2,183 women consented and attended the first examination (mean age: 40 (standard deviation: 9) years; range: 19-72 years). The examination included clinical and laboratory assessments of vascular risk factors and imaging for subclinical atherosclerosis, as well as assessment of cardiac structure and function. The comparison of Third Generation Cohort data with measures previously collected from the first two generations will facilitate investigations of genetic and environmental risk factors for subclinical and overt diseases, with a focus on cardiovascular and lung disorders.
KW - Atherosclerosis
KW - Cardiovascular diseases
KW - Cohort studies
KW - Epidemiologic research design
KW - Patient selection
KW - Physical examination
KW - Risk factors
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U2 - 10.1093/aje/kwm021
DO - 10.1093/aje/kwm021
M3 - Article
C2 - 17372189
AN - SCOPUS:34247579476
SN - 0002-9262
VL - 165
SP - 1328
EP - 1335
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 11
ER -