The Therapeutic Use of Red Blood Cells

G. M. Meny; L. Liao

doi:10.1016/B978-0-12-386456-7.06205-5

The Therapeutic Use of Red Blood Cells

G. M. Meny, L. Liao

Pathology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A primary indication for red blood cell (RBC) transfusion is to prevent the adverse effects of inadequate tissue oxygenation when hemoglobin (Hgb) is low and physiological mechanisms to compensate for diminished oxygen deLivery are inadequate. Indications for transfusion have historically been guided by Hgb concentration. The conundrum facing researchers and healthcare providers is to identify the point when critical tissue oxygen deLivery is impaired to the extent that transfusion is required in a patient while avoiding unnecessary transfusion. This article will review basic physiological responses to RBC loss and indications for RBC transfusion in patients with acute and chronic anemia and conclude with a discussion of alternatives to transfusion.

Original language	English (US)
Title of host publication	Pathobiology of Human Disease
Subtitle of host publication	A Dynamic Encyclopedia of Disease Mechanisms
Publisher	Elsevier Inc.
Pages	3088-3100
Number of pages	13
ISBN (Electronic)	9780123864567
ISBN (Print)	9780123864574
DOIs	https://doi.org/10.1016/B978-0-12-386456-7.06205-5
State	Published - Jan 1 2014

Keywords

Acute anemia
Autologous transfusion
Blood substitute
Chronic anemia
Critical hemoglobin concentration
Massive transfusion protocol
Pharmacological therapies
Red blood cells
Transfusion

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-386456-7.06205-5

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abstract = "A primary indication for red blood cell (RBC) transfusion is to prevent the adverse effects of inadequate tissue oxygenation when hemoglobin (Hgb) is low and physiological mechanisms to compensate for diminished oxygen deLivery are inadequate. Indications for transfusion have historically been guided by Hgb concentration. The conundrum facing researchers and healthcare providers is to identify the point when critical tissue oxygen deLivery is impaired to the extent that transfusion is required in a patient while avoiding unnecessary transfusion. This article will review basic physiological responses to RBC loss and indications for RBC transfusion in patients with acute and chronic anemia and conclude with a discussion of alternatives to transfusion.",

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