The Syrian hamster pineal gland responds to isoproterenol in vivo at night

G. M. Vaughan, Russel J Reiter

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Failure of isoproterenol (ISO) injections to raise pineal melatonin content has generated doubt about β-adrenergic control of the melatonin rhythm in Syrian hamsters. However, the effect of ISO injected at night after light-induced reduction of pineal melatonin has not been reported. In this study, light exposure began at 6 1/4 h into one (normally 10-h) dark phase. The hamsters were injected with either ISO (1 mg/kg) or vehicle 15 min later when pineal melatonin content was low. Light exposure continued. Two h after ISO but not vehicle injection, pineal melatonin content rose more than six-fold. In other animals injected at the end of the usual light phase then kept in light for 2 h, pineal melatonin was equally low after ISO or vehicle injection. The Syrian hamster pineal gland can respond in vivo to a β-adrenergic agonist injected at the physiologically relevant time of the normal nocturnal melatonin surge. This finding, taken together with the previously reported inhibition of the endogenous nocturnal melatonin surge with a β-blocking drug, suggests that a β-adrenergic mechanism controls the hamster pineal melatonin rhythm.

Original languageEnglish (US)
Pages (from-to)1682-1684
Number of pages3
JournalEndocrinology
Volume120
Issue number4
StatePublished - 1987

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Pineal Gland
Mesocricetus
Melatonin
Isoproterenol
Light
Cricetinae
Adrenergic Agents
Injections
Adrenergic Agonists

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The Syrian hamster pineal gland responds to isoproterenol in vivo at night. / Vaughan, G. M.; Reiter, Russel J.

In: Endocrinology, Vol. 120, No. 4, 1987, p. 1682-1684.

Research output: Contribution to journalArticle

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