The synthesis of deuterium-labeled spermine, N1 -acetylspermine and N1-acetylspermidine

Vijay Gawandi, Paul F. Fitzpatrick

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The synthesis of deuterium-labeled spermine, N1-acetylspermine and N1-acetylspermidine is reported. 1,1,3,3-2H 4-N1-Acetylspermine hydrochloride, 1,1,3,3- 2H4-N1-acetylspermidine hydrochloride and 1,1,3,3,10,10,12,12-2H8-spermine dihydrochloride were obtained in seven, four and three steps, respectively. All the syntheses were carried out by simple protection and deprotection steps from commonly used selective protecting reagents. These deuterium-labeled compounds can be used as mechanistic probes of polyamine oxidizing enzymes.

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume50
Issue number7
DOIs
StatePublished - Jun 2007

Keywords

  • Deuterium labeling
  • N -acetylspermidine
  • N-acetylspermine
  • Polyamine oxidase
  • Spermine

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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