The sweetest thing: blocking fructose metabolism to prevent acute kidney injury?

Christina M. Wyatt, William B Reeves

Research output: Contribution to journalComment/debate

2 Citations (Scopus)

Abstract

Fructose consumption has been linked to hypertension in animal models and human studies, and endogenous fructose metabolism has been shown to promote acute and chronic kidney injury in mice. A recent study published in Nature Communications demonstrates a reduction in ischemic acute kidney injury with genetic knockout or inhibition of fructokinase, which catalyzes the first step in fructose metabolism. Although the role of this pathway in human kidney disease remains unclear, the recent description of several candidate fructokinase inhibitors may allow for clinical studies in the future.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalKidney International
Volume91
Issue number5
DOIs
StatePublished - May 1 2017

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fructokinase
Fructose
Acute Kidney Injury
Kidney Diseases
Animal Models
Communication
Hypertension

ASJC Scopus subject areas

  • Nephrology

Cite this

The sweetest thing : blocking fructose metabolism to prevent acute kidney injury? / Wyatt, Christina M.; Reeves, William B.

In: Kidney International, Vol. 91, No. 5, 01.05.2017, p. 998-1000.

Research output: Contribution to journalComment/debate

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