The suppression of pineal melatonin content and n-acetyitransferase activity by different light irradiances in the syrian hamster: A dose-response relationship

George C. Brainard; Bruce A. Richardson; Thomas S. King; Susan A. Matthews; Russel J. Reiter

doi:10.1210/endo-113-1-293

The suppression of pineal melatonin content and n-acetyitransferase activity by different light irradiances in the syrian hamster: A dose-response relationship

George C. Brainard, Bruce A. Richardson, Thomas S. King, Susan A. Matthews, Russel J. Reiter

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

The purpose of this study was to test the influence of various irradiances of cool white fluorescent light on the suppression of pineal N-acetyltransferase activity (NAT) and melatonin content in hamsters. Groups of animals were exposed to light irradiances ranging from 0.00–1.86 microwatts (μW)/cm² for 20 min during the night. Both pineal NAT and melatonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED₅₀ for NAT (0.066 μW/cm²) and melatonin (0.058 μW/cm²) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination. (Endocrinology 113: 293, 1983).

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Endocrinology
Volume	113
Issue number	1
DOIs	https://doi.org/10.1210/endo-113-1-293
State	Published - Jul 1983

ASJC Scopus subject areas

Endocrinology

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title = "The suppression of pineal melatonin content and n-acetyitransferase activity by different light irradiances in the syrian hamster: A dose-response relationship",

abstract = "The purpose of this study was to test the influence of various irradiances of cool white fluorescent light on the suppression of pineal N-acetyltransferase activity (NAT) and melatonin content in hamsters. Groups of animals were exposed to light irradiances ranging from 0.00–1.86 microwatts (μW)/cm2 for 20 min during the night. Both pineal NAT and melatonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED50 for NAT (0.066 μW/cm2) and melatonin (0.058 μW/cm2) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination. (Endocrinology 113: 293, 1983).",

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AU - Richardson, Bruce A.

AU - King, Thomas S.

AU - Matthews, Susan A.

AU - Reiter, Russel J.

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AB - The purpose of this study was to test the influence of various irradiances of cool white fluorescent light on the suppression of pineal N-acetyltransferase activity (NAT) and melatonin content in hamsters. Groups of animals were exposed to light irradiances ranging from 0.00–1.86 microwatts (μW)/cm2 for 20 min during the night. Both pineal NAT and melatonin were similarly depressed by the light irradiances in a dose-related manner. The shape of the resultant dose-response curves and the calculated ED50 for NAT (0.066 μW/cm2) and melatonin (0.058 μW/cm2) were remarkably similar. These findings may be relevant to the physiological control of the pineal by natural illumination. (Endocrinology 113: 293, 1983).

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The suppression of pineal melatonin content and n-acetyitransferase activity by different light irradiances in the syrian hamster: A dose-response relationship

Abstract

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